An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques.
RSC Adv
; 11(33): 20457-20464, 2021 Jun 08.
Article
in English
| MEDLINE | ID: covidwho-1387504
ABSTRACT
An improved and expedient technique for the synthesis of peptidyl-fluoromethyl ketones is described. The methodology is based on prior coupling of an aspartate fluoromethyl ketone to a linker and mounting it onto resin-bound methylbenzhydrylamine hydrochloride. Subsequently, by utilising standard Fmoc peptide procedures, a number of short Z-protected peptides were synthesised and assessed as possible inhibitors of the main protease from SARS-CoV-2 (3CLpro).
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International databases
Database:
MEDLINE
Language:
English
Journal:
RSC Adv
Year:
2021
Document Type:
Article
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