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Persistent cellular immunity to SARS-CoV-2 infection.
Breton, Gaëlle; Mendoza, Pilar; Hägglöf, Thomas; Oliveira, Thiago Y; Schaefer-Babajew, Dennis; Gaebler, Christian; Turroja, Martina; Hurley, Arlene; Caskey, Marina; Nussenzweig, Michel C.
  • Breton G; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Mendoza P; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Hägglöf T; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Oliveira TY; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Schaefer-Babajew D; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Gaebler C; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Turroja M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Hurley A; Hospital Program Direction, The Rockefeller University, New York, NY.
  • Caskey M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Nussenzweig MC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
J Exp Med ; 218(4)2021 04 05.
Article in English | MEDLINE | ID: covidwho-1387677
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ABSTRACT
SARS-CoV-2 is responsible for an ongoing pandemic that has affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals, we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 mo after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen-specific memory that could contribute to rapid recall responses. Recovered individuals also show enduring alterations in relative overall numbers of CD4+ and CD8+ memory T cells, including expression of activation/exhaustion markers, and cell division.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Host-Pathogen Interactions / SARS-CoV-2 / COVID-19 / Immunity, Cellular Type of study: Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Host-Pathogen Interactions / SARS-CoV-2 / COVID-19 / Immunity, Cellular Type of study: Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Year: 2021 Document Type: Article