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Reliability of Self-Sampling for Accurate Assessment of Respiratory Virus Viral and Immunologic Kinetics.
Waghmare, Alpana; Krantz, Elizabeth M; Baral, Subhasish; Vasquez, Emma; Loeffelholz, Tillie; Chung, E Lisa; Pandey, Urvashi; Kuypers, Jane; Duke, Elizabeth R; Jerome, Keith R; Greninger, Alexander L; Reeves, Daniel B; Hladik, Florian; Cardozo-Ojeda, E Fabian; Boeckh, Michael; Schiffer, Joshua T.
  • Waghmare A; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Krantz EM; Department of Pediatrics, University of Washington, Seattle, Washington, USA.
  • Baral S; Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, Washington, USA.
  • Vasquez E; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Loeffelholz T; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Chung EL; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Pandey U; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Kuypers J; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Duke ER; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Jerome KR; Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA.
  • Greninger AL; Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
  • Reeves DB; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Hladik F; Department of Medicine, University of Washington, Seattle, Washington, USA.
  • Cardozo-Ojeda EF; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Boeckh M; Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
  • Schiffer JT; Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
J Infect Dis ; 226(2): 278-286, 2022 08 24.
Article in English | MEDLINE | ID: covidwho-1387897
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ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic demonstrates the need for accurate and convenient approaches to diagnose and therapeutically monitor respiratory viral infections. We demonstrated that self-sampling with mid-nasal foam swabs is well-tolerated and provides quantitative viral output concordant with flocked swabs. Using longitudinal home-based self-sampling, we demonstrate that nasal cytokine levels correlate and cluster according to immune cell of origin. Periods of stable viral loads are followed by rapid elimination, which could be coupled with cytokine expansion and contraction. Nasal foam swab self-sampling at home provides a precise, mechanistic readout of respiratory virus shedding and local immune responses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viruses / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: INFDIS

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viruses / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: INFDIS