Your browser doesn't support javascript.
Optimal serum ferritin level range: iron status measure and inflammatory biomarker.
DePalma, Ralph G; Hayes, Virginia W; O'Leary, Timothy J.
  • DePalma RG; Office of Research and Development, Department of Veterans Affairs, Washington, DC 20420, USA.
  • Hayes VW; Department of Surgery, Uniformed University of the Health Sciences, Bethesda, MD 20814, USA.
  • O'Leary TJ; Virginia W Hayes, Ambulatory Care Service, Sierra Nevada Health Care System, Reno, NV 89502, USA.
Metallomics ; 13(6)2021 06 11.
Article in English | MEDLINE | ID: covidwho-1387958
ABSTRACT
This report provides perspectives concerning dual roles of serum ferritin as a measure of both iron status and inflammation. We suggest benefits of a lower range of serum ferritin as has occurred for total serum cholesterol and fasting blood glucose levels. Observations during a prospective randomized study using phlebotomy in patients with peripheral arterial disease offered unique insights into dual roles of serum ferritin both as an iron status marker and acute phase reactant. Robust positive associations between serum ferritin, interleukin 6 [IL-6], tissue necrosis factor-alpha, and high sensitivity C-reactive protein were discovered. Elevated serum ferritin and IL-6 levels associated with increased mortality and with reduced mortality at ferritin levels <100 ng mL-1. Epidemiologic studies demonstrate similar outcomes. Extremely elevated ferritin and IL-6 levels also occur in individuals with high mortality due to SARS-CoV-2 infection. Disordered iron metabolism reflected by a high range of serum ferritin level signals disease severity and outcomes. Based upon experimental and epidemiologic data, we suggest testing the hypotheses that optimal ferritin levels for cardiovascular mortality reduction range from 20 to 100 ng mL-1 with % transferrin levels from 20 to 50%, to ensure adequate iron status and that ferritin levels above 194 ng mL-1 associate with all-cause mortality in population cohorts.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Peripheral Arterial Disease / Ferritins / Inflammation / Iron Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal subject: Biochemistry Year: 2021 Document Type: Article Affiliation country: MTOMCS

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Peripheral Arterial Disease / Ferritins / Inflammation / Iron Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal subject: Biochemistry Year: 2021 Document Type: Article Affiliation country: MTOMCS