An update on ACE2 amplification and its therapeutic potential.
Acta Physiol (Oxf)
; 231(1): e13513, 2021 01.
Article
in English
| MEDLINE | ID: covidwho-1388186
ABSTRACT
The renin angiotensin system (RAS) plays an important role in the pathogenesis of variety of diseases. Targeting the formation and action of angiotensin II (Ang II), the main RAS peptide, has been the key therapeutic target for last three decades. ACE-related carboxypeptidase (ACE2), a monocarboxypeptidase that had been discovered 20 years ago, is one of the catalytically most potent enzymes known to degrade Ang II to Ang-(1-7), a peptide that is increasingly accepted to have organ-protective properties that oppose and counterbalance those of Ang II. In addition to its role as a RAS enzyme ACE2 is the main receptor for SARS-CoV-2. In this review, we discuss various strategies that have been used to achieve amplification of ACE2 activity including the potential therapeutic potential of soluble recombinant ACE2 protein and novel shorter ACE2 variants.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Receptors, Virus
/
Genetic Therapy
/
Virus Internalization
/
Angiotensin-Converting Enzyme 2
/
SARS-CoV-2
/
COVID-19
/
COVID-19 Drug Treatment
Topics:
Variants
Limits:
Animals
/
Humans
Language:
English
Journal:
Acta Physiol (Oxf)
Journal subject:
Physiology
Year:
2021
Document Type:
Article
Affiliation country:
APHA.13513
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