The relationship between human coronaviruses, asthma and allergy-An unresolved dilemma.
Clin Exp Allergy
; 50(10): 1122-1126, 2020 10.
Article
in English
| MEDLINE | ID: covidwho-1388225
ABSTRACT
Human coronaviruses (HCoVs) such as HCoV-229E or OC43 are responsible for mild upper airway infections, whereas highly pathogenic HCoVs, including SARS-CoV, MERS-CoV and SARS-CoV-2, often evoke acute, heavy pneumonias. They tend to induce immune responses based on interferon and host inflammatory cytokine production and promotion of T1 immune profile. Less is known about their effect on T2-type immunity. Unlike human rhinoviruses (HRV) and Respiratory Syncytial Virus (RSV), HCoVs are not considered as a dominant risk factor of severe exacerbations of asthma, mostly T2-type chronic inflammatory disease. The relationship between coronaviruses and T2-type immunity, especially in asthma and allergy, is not well understood. This review aims to summarize currently available knowledge about the relationship of HCoVs, including novel SARS-CoV-2, with asthma and allergic inflammation.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Asthma
/
SARS-CoV-2
/
COVID-19
/
Hypersensitivity
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Clin Exp Allergy
Journal subject:
Allergy and Immunology
Year:
2020
Document Type:
Article
Affiliation country:
CEA.13718
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