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Protocol for a prospective, observational, hospital-based multicentre study of nosocomial SARS-CoV-2 transmission: NOSO-COR Project.
Saadatian-Elahi, Mitra; Picot, Valentina; Hénaff, Laetitia; Pradel, Florence K; Escuret, Vanessa; Dananché, Cédric; Elias, Christelle; Endtz, Hubert P; Vanhems, Philippe.
  • Saadatian-Elahi M; Laboratoire des Pathogènes Emergents, Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS, Lyon, France.
  • Picot V; Service Hygiène, Epidémiologie et Prévention, Centre Hospitalier Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
  • Hénaff L; Laboratoire des Pathogènes Emergents, Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS, Lyon, France.
  • Pradel FK; Fondation Merieux, Lyon, Rhône-Alpes, France.
  • Escuret V; Laboratoire des Pathogènes Emergents, Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS, Lyon, France.
  • Dananché C; Laboratoire des Pathogènes Emergents, Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS, Lyon, France.
  • Elias C; Fondation Merieux, Lyon, Rhône-Alpes, France.
  • Endtz HP; Laboratoire de Virologie, Institut des Agents Infectieux, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.
  • Vanhems P; Virpath, Grippe, de l'émergence au contrôle, Centre International de Recherche en Infectiologie (CIRI), Inserm U111, CNRS 5308, ENS, UCBL1, Faculté de Médecine RTH Laënnec, Lyon, France.
BMJ Open ; 10(10): e039088, 2020 10 22.
Article in English | MEDLINE | ID: covidwho-1388509
ABSTRACT

INTRODUCTION:

The newly identified SARS-CoV-2 can cause serious acute respiratory infections such as pneumonia. In France, mortality rate in the general population was approximately 10% and could reach higher levels at the hospital. In the current context of high incidence rates of SARS-CoV-2 in the community, a significant increase in the rate of nosocomial transmission is expected. The risk of nosocomial transmission could even be higher in low-income countries that have fragile healthcare systems. This protocol is intended to estimate the prevalence and incidence of suspected or confirmed cases of nosocomial SARS-CoV-2 infection, the clinical spectrum and the determinants (risk factors/protective) at participating hospitals. METHODS AND

ANALYSIS:

This will be an international multicentre prospective, observational, hospital-based study in adults and children. It will include volunteer patients and healthcare professionals in France and hospitals affiliated with the GABRIEL network. Demographic and clinical data will be collected using case report forms designed especially for the purpose of the project. A nasopharyngeal swab will be collected and tested for SARS-CoV-2 by reverse-transcriptase PCR. Characteristics of the study participants, the proportion of confirmed nosocomial SARS-CoV-2 infections relative to all patients with syndromes suggestive of SARS-CoV-2 infection, will be analysed. Appropriate multivariate modelling will be used to identify the determinants associated with nosocomial onset. ETHICS AND DISSEMINATION This study was approved by the clinical research and committee of all participating countries. The findings will be submitted to peer-reviewed journal for publication and shared with national health authorities. TRIAL REGISTRATION NUMBER NCT04290780.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cross Infection / Coronavirus Infections / Pandemics / Betacoronavirus / Hospitals Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Child / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: BMJ Open Year: 2020 Document Type: Article Affiliation country: BMJOPEN-2020-039088

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cross Infection / Coronavirus Infections / Pandemics / Betacoronavirus / Hospitals Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Child / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: BMJ Open Year: 2020 Document Type: Article Affiliation country: BMJOPEN-2020-039088