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SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2.
Lei, Yuyang; Zhang, Jiao; Schiavon, Cara R; He, Ming; Chen, Lili; Shen, Hui; Zhang, Yichi; Yin, Qian; Cho, Yoshitake; Andrade, Leonardo; Shadel, Gerald S; Hepokoski, Mark; Lei, Ting; Wang, Hongliang; Zhang, Jin; Yuan, Jason X-J; Malhotra, Atul; Manor, Uri; Wang, Shengpeng; Yuan, Zu-Yi; Shyy, John Y-J.
  • Lei Y; Cardiology, First Affiliated Hospital of Xi'an Jiaotong University (Y.L., Jiao Zhang, Z.-Y.Y.).
  • Zhang J; Cardiovascular Research Center, School of Basic Medical Sciences (Y.L., Jiao Zhang, L.C., Q.Y., S.W.).
  • Schiavon CR; Cardiology, First Affiliated Hospital of Xi'an Jiaotong University (Y.L., Jiao Zhang, Z.-Y.Y.).
  • He M; Cardiovascular Research Center, School of Basic Medical Sciences (Y.L., Jiao Zhang, L.C., Q.Y., S.W.).
  • Chen L; Xi'an Jiaotong University Health Science Center. Cardiology, Department of Medicine (Jiao Zhang, M. He, H.S., Y.Z., Y.C., J.Y.-J.S.), University of California, San Diego, La Jolla, CA.
  • Shen H; Waitt Advanced Biophotonics Center (C.R.S., L.A., U.M.).
  • Zhang Y; Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA (C.R.S., G.S.S.).
  • Yin Q; Xi'an Jiaotong University Health Science Center. Cardiology, Department of Medicine (Jiao Zhang, M. He, H.S., Y.Z., Y.C., J.Y.-J.S.), University of California, San Diego, La Jolla, CA.
  • Cho Y; Cardiovascular Research Center, School of Basic Medical Sciences (Y.L., Jiao Zhang, L.C., Q.Y., S.W.).
  • Andrade L; Xi'an Jiaotong University Health Science Center. Cardiology, Department of Medicine (Jiao Zhang, M. He, H.S., Y.Z., Y.C., J.Y.-J.S.), University of California, San Diego, La Jolla, CA.
  • Shadel GS; Cardiology, the Affiliated Hospital of Yangzhou University (H.S.).
  • Hepokoski M; Xi'an Jiaotong University Health Science Center. Cardiology, Department of Medicine (Jiao Zhang, M. He, H.S., Y.Z., Y.C., J.Y.-J.S.), University of California, San Diego, La Jolla, CA.
  • Lei T; Cardiovascular Research Center, School of Basic Medical Sciences (Y.L., Jiao Zhang, L.C., Q.Y., S.W.).
  • Wang H; Xi'an Jiaotong University Health Science Center. Cardiology, Department of Medicine (Jiao Zhang, M. He, H.S., Y.Z., Y.C., J.Y.-J.S.), University of California, San Diego, La Jolla, CA.
  • Zhang J; Waitt Advanced Biophotonics Center (C.R.S., L.A., U.M.).
  • Yuan JX; Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA (C.R.S., G.S.S.).
  • Malhotra A; Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (M. Hepokoski, J.X.-J.Y., A.M.), University of California, San Diego, La Jolla, CA.
  • Manor U; Pathology, School of Basic Medical Sciences (T.L.), University of California, San Diego, La Jolla, CA.
  • Wang S; Pathogen Biology and Immunology, School of Basic Medical Sciences (H.W.), University of California, San Diego, La Jolla, CA.
  • Yuan ZY; Pharmacology (Jin Zhang), University of California, San Diego, La Jolla, CA.
  • Shyy JY; Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (M. Hepokoski, J.X.-J.Y., A.M.), University of California, San Diego, La Jolla, CA.
Circ Res ; 128(9): 1323-1326, 2021 04 30.
Article in English | MEDLINE | ID: covidwho-1388580
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endothelium, Vascular / Down-Regulation / Spike Glycoprotein, Coronavirus / Angiotensin-Converting Enzyme 2 Limits: Animals Language: English Journal: Circ Res Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endothelium, Vascular / Down-Regulation / Spike Glycoprotein, Coronavirus / Angiotensin-Converting Enzyme 2 Limits: Animals Language: English Journal: Circ Res Year: 2021 Document Type: Article