Azithromycin Downregulates Gene Expression of IL-1ß and Pathways Involving TMPRSS2 and TMPRSS11D Required by SARS-CoV-2.

Renteria, Axel E; Mfuna Endam, Leandra; Adam, Damien; Filali-Mouhim, Ali; Maniakas, Anastasios; Rousseau, Simon; Brochiero, Emmanuelle; Gallo, Stefania; Desrosiers, Martin

Renteria, Axel E; Mfuna Endam, Leandra; Adam, Damien; Filali-Mouhim, Ali; Maniakas, Anastasios; Rousseau, Simon; Brochiero, Emmanuelle; Gallo, Stefania; Desrosiers, Martin.

Renteria AE; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada.
Mfuna Endam L; Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, Quebec, Canada.
Adam D; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada.
Filali-Mouhim A; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada.
Maniakas A; Université de Montréal, Montréal, Quebec, Canada.
Rousseau S; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada.
Brochiero E; Centre intégré universitaire de service de santé et sociaux (CIUSSS) de l'Est-de-l'île-de-Montréal associé à l'Université de Montréal, Montréal, Quebec, Canada.
Gallo S; McGill University, Montreal, Quebec, Canada.
Desrosiers M; McGill University, Montreal, Quebec, Canada.

Am J Respir Cell Mol Biol ; 63(5): 707-709, 2020 11.

Article in English | MEDLINE | ID: covidwho-1388616

Subject(s)

Anti-Inflammatory Agents/pharmacology; Azithromycin/pharmacology; Coronavirus Infections/drug therapy; Interleukin-1beta/metabolism; Membrane Proteins/metabolism; Nasal Mucosa/drug effects; Pneumonia, Viral/drug therapy; Serine Endopeptidases/metabolism; Serine Proteases/metabolism; Betacoronavirus/pathogenicity; COVID-19; Cells, Cultured; Chronic Disease; Coronavirus Infections/immunology; Coronavirus Infections/metabolism; Coronavirus Infections/virology; Down-Regulation; Host-Pathogen Interactions; Humans; Interleukin-1beta/genetics; Male; Membrane Proteins/genetics; Nasal Mucosa/immunology; Nasal Mucosa/metabolism; Pandemics; Pilot Projects; Pneumonia, Viral/immunology; Pneumonia, Viral/metabolism; Pneumonia, Viral/virology; Rhinitis/drug therapy; Rhinitis/immunology; Rhinitis/metabolism; SARS-CoV-2; Serine Endopeptidases/genetics; Serine Proteases/genetics; Signal Transduction; Sinusitis/drug therapy; Sinusitis/immunology; Sinusitis/metabolism; COVID-19 Drug Treatment

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Serine Endopeptidases / Coronavirus Infections / Azithromycin / Interleukin-1beta / Serine Proteases / Membrane Proteins / Anti-Inflammatory Agents / Nasal Mucosa Language: English Journal: Am J Respir Cell Mol Biol Journal subject: Molecular Biology Year: 2020 Document Type: Article Affiliation country: RCMB.2020-0285LE

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