SARS-CoV-2 and interferon blockade.

Diamond, Betty; Volpe, Bruce T; VanPatten, Sonya; Al Abed, Yousef

Diamond, Betty; Volpe, Bruce T; VanPatten, Sonya; Al Abed, Yousef.

Diamond B; Center for Molecular Medicine, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
Volpe BT; Center for Molecular Medicine, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA. bvolpe1@northwell.edu.
VanPatten S; Center for Bioelectronic Medicine, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
Al Abed Y; Center for Bioelectronic Medicine, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.

Mol Med ; 26(1): 103, 2020 11 09.

Article in English | MEDLINE | ID: covidwho-1388721

ABSTRACT

ABSTRACT

The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. This model has therapeutic implications.

Subject(s)

Betacoronavirus/immunology; Coronavirus Infections/immunology; Immunity, Innate; Pneumonia, Viral/immunology; Animals; Bradykinin/metabolism; COVID-19; Humans; Kallikreins/metabolism; Models, Immunological; Pandemics; Renin-Angiotensin System; SARS-CoV-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Immunity, Innate Limits: Animals / Humans Language: English Journal: Mol Med Journal subject: Molecular Biology Year: 2020 Document Type: Article Affiliation country: S10020-020-00231-W

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