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Echinacea purpurea (L.) Moench treatment of monocytes promotes tonic interferon signaling, increased innate immunity gene expression and DNA repeat hypermethylated silencing of endogenous retroviral sequences.
Declerck, Ken; Novo, Claudina Perez; Grielens, Lisa; Van Camp, Guy; Suter, Andreas; Vanden Berghe, Wim.
  • Declerck K; Laboratory of Protein Chemistry, Proteomics and Epigenetic Signaling (PPES), Department of Biomedical Sciences, University of Antwerp (UA), Antwerp, Belgium.
  • Novo CP; Laboratory of Protein Chemistry, Proteomics and Epigenetic Signaling (PPES), Department of Biomedical Sciences, University of Antwerp (UA), Antwerp, Belgium.
  • Grielens L; Laboratory of Protein Chemistry, Proteomics and Epigenetic Signaling (PPES), Department of Biomedical Sciences, University of Antwerp (UA), Antwerp, Belgium.
  • Van Camp G; Center of Medical Genetics, Department of Biomedical Sciences, University of Antwerp (UA) and University Hospital Antwerp (UZA), Antwerp, Belgium.
  • Suter A; A. Vogel Bioforce AG, Roggwil, Switzerland.
  • Vanden Berghe W; Laboratory of Protein Chemistry, Proteomics and Epigenetic Signaling (PPES), Department of Biomedical Sciences, University of Antwerp (UA), Antwerp, Belgium. Wim.vandenberghe@uantwerpen.be.
BMC Complement Med Ther ; 21(1): 141, 2021 May 12.
Article in English | MEDLINE | ID: covidwho-1388756
Semantic information from SemMedBD (by NLM)
1. DNA Sequence PART_OF Endogenous Retroviruses
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DNA Sequence
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PART_OF
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Endogenous Retroviruses
2. DNA Sequence LOCATION_OF silence
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DNA Sequence
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LOCATION_OF
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silence
3. Today PREVENTS Respiratory Tract Infections
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Today
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PREVENTS
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Respiratory Tract Infections
4. Kinome AFFECTS Immunoregulation
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Kinome
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AFFECTS
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Immunoregulation
5. Epigenome AFFECTS Immunoregulation
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Epigenome
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AFFECTS
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Immunoregulation
6. IFNA1 STIMULATES Receptor
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IFNA1
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STIMULATES
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Receptor
7. JAK1 gene|JAK1 AFFECTS Immune
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JAK1 gene|JAK1
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AFFECTS
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Immune
8. Monocytes LOCATION_OF Human Endogenous Retroviruses
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Monocytes
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LOCATION_OF
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Human Endogenous Retroviruses
9. DNA Sequence PART_OF Endogenous Retroviruses
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DNA Sequence
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PART_OF
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Endogenous Retroviruses
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DNA Sequence
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silence
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Today
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PREVENTS
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Respiratory Tract Infections
12. Kinome AFFECTS Immunoregulation
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Kinome
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AFFECTS
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Immunoregulation
13. Epigenome AFFECTS Immunoregulation
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Epigenome
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AFFECTS
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Immunoregulation
14. IFNA1 STIMULATES Receptors, Pattern Recognition
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IFNA1
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STIMULATES
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Receptors, Pattern Recognition
15. JAK1 gene|JAK1 AFFECTS Immune
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JAK1 gene|JAK1
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AFFECTS
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Immune
16. Monocytes LOCATION_OF Human Endogenous Retroviruses
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Monocytes
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LOCATION_OF
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Human Endogenous Retroviruses
ABSTRACT

BACKGROUND:

Herbal remedies of Echinacea purpurea tinctures are widely used today to reduce common cold respiratory tract infections.

METHODS:

Transcriptome, epigenome and kinome profiling allowed a systems biology level characterisation of genomewide immunomodulatory effects of a standardized Echinacea purpurea (L.) Moench extract in THP1 monocytes.

RESULTS:

Gene expression and DNA methylation analysis revealed that Echinaforce® treatment triggers antiviral innate immunity pathways, involving tonic IFN signaling, activation of pattern recognition receptors, chemotaxis and immunometabolism. Furthermore, phosphopeptide based kinome activity profiling and pharmacological inhibitor experiments with filgotinib confirm a key role for Janus Kinase (JAK)-1 dependent gene expression changes in innate immune signaling. Finally, Echinaforce® treatment induces DNA hypermethylation at intergenic CpG, long/short interspersed nuclear DNA repeat elements (LINE, SINE) or long termininal DNA repeats (LTR). This changes transcription of flanking endogenous retroviral sequences (HERVs), involved in an evolutionary conserved (epi) genomic protective response against viral infections.

CONCLUSIONS:

Altogether, our results suggest that Echinaforce® phytochemicals strengthen antiviral innate immunity through tonic IFN regulation of pattern recognition and chemokine gene expression and DNA repeat hypermethylated silencing of HERVs in monocytes. These results suggest that immunomodulation by Echinaforce® treatment holds promise to reduce symptoms and duration of infection episodes of common cold corona viruses (CoV), Severe Acute Respiratory Syndrome (SARS)-CoV, and new occurring strains such as SARS-CoV-2, with strongly impaired interferon (IFN) response and weak innate antiviral defense.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Plant Extracts / Monocytes / Echinacea / SARS-CoV-2 / COVID-19 / Immunologic Factors Topics: Long Covid / Traditional medicine Limits: Humans Language: English Journal: BMC Complement Med Ther Year: 2021 Document Type: Article Affiliation country: S12906-021-03310-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Plant Extracts / Monocytes / Echinacea / SARS-CoV-2 / COVID-19 / Immunologic Factors Topics: Long Covid / Traditional medicine Limits: Humans Language: English Journal: BMC Complement Med Ther Year: 2021 Document Type: Article Affiliation country: S12906-021-03310-5