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SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans.
Konishi, Tomokazu.
  • Konishi T; Graduate School of Bioresource Sciences, Akita Prefectural University, Akita, Japan.
PLoS One ; 16(5): e0247626, 2021.
Article in English | MEDLINE | ID: covidwho-1388902
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ABSTRACT
SARS-CoV-2 infection in minks has become a serious problem, as the virus may mutate and reinfect humans; some countries have decided to cull minks. Here, the virus sequencing data in minks were analysed and compared to those of human-virus. Although the mink-virus maintained the characteristics of human-virus, some variants rapidly mutated, adapting to minks. Some mink-derived variants infected humans, which accounted for 40% of the total SARS-CoV-2 cases in the Netherlands. These variants appear to be less lethal and infective compared to those in humans. Variants that have mutated further among minks were not found in humans. Such mink-viruses might be suitable for vaccination for humans, such as in the case of the smallpox virus, which is less infective and toxic to humans.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA, Viral / SARS-CoV-2 / COVID-19 / Mink Type of study: Observational study Topics: Vaccines / Variants Limits: Animals / Humans Country/Region as subject: Europa Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: JOURNAL.PONE.0247626

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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA, Viral / SARS-CoV-2 / COVID-19 / Mink Type of study: Observational study Topics: Vaccines / Variants Limits: Animals / Humans Country/Region as subject: Europa Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: JOURNAL.PONE.0247626