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Predictors of infection, symptoms development, and mortality in people with SARS-CoV-2 living in retirement nursing homes.
De Vito, Andrea; Fiore, Vito; Princic, Elija; Geremia, Nicholas; Panu Napodano, Catello Mario; Muredda, Alberto Augusto; Maida, Ivana; Madeddu, Giordano; Babudieri, Sergio.
  • De Vito A; Unit of Infectious Diseases, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
  • Fiore V; Unit of Infectious Diseases, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
  • Princic E; Unit of Infectious Diseases, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
  • Geremia N; Unit of Infectious Diseases, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
  • Panu Napodano CM; Unit of Infectious Diseases, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
  • Muredda AA; Unit of Infectious Diseases, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
  • Maida I; Unit of Infectious Diseases, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
  • Madeddu G; Unit of Infectious Diseases, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
  • Babudieri S; Mediterranean Center for Disease Control, University of Sassari, Sassari, Italy.
PLoS One ; 16(3): e0248009, 2021.
Article in English | MEDLINE | ID: covidwho-1575841
Semantic information from SemMedBD (by NLM)
1. Household composition PROCESS_OF Persons
Subject
Household composition
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PROCESS_OF
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Persons
2. Symptoms PROCESS_OF Persons
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Symptoms
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PROCESS_OF
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Persons
3. Infected PROCESS_OF Persons
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Infected
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PROCESS_OF
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Persons
4. American College of Cardiology/American Heart Association Lesion Complexity Score A COEXISTS_WITH Syndrome
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American College of Cardiology/American Heart Association Lesion Complexity Score A
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COEXISTS_WITH
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Syndrome
5. Angiotensin II receptor antagonist PREDISPOSES COVID-19
Subject
Angiotensin II receptor antagonist
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PREDISPOSES
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COVID-19
6. COVID-19 PROCESS_OF Persons
Subject
COVID-19
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PROCESS_OF
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Persons
7. Disease COEXISTS_WITH Dyspnea
Subject
Disease
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COEXISTS_WITH
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Dyspnea
8. Disease COEXISTS_WITH Fever
Subject
Disease
Predicate
COEXISTS_WITH
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Fever
9. Nursing Homes LOCATION_OF Administration occupational activities
Subject
Nursing Homes
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LOCATION_OF
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Administration occupational activities
10. Household composition PROCESS_OF Persons
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Household composition
Predicate
PROCESS_OF
Object
Persons
11. Symptoms PROCESS_OF Persons
Subject
Symptoms
Predicate
PROCESS_OF
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Persons
12. Infected PROCESS_OF Persons
Subject
Infected
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PROCESS_OF
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Persons
13. American College of Cardiology/American Heart Association Lesion Complexity Score A COEXISTS_WITH Syndrome
Subject
American College of Cardiology/American Heart Association Lesion Complexity Score A
Predicate
COEXISTS_WITH
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Syndrome
14. Angiotensin II receptor antagonist PREDISPOSES COVID-19
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Angiotensin II receptor antagonist
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PREDISPOSES
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COVID-19
15. COVID-19 PROCESS_OF Persons
Subject
COVID-19
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PROCESS_OF
Object
Persons
16. Disease COEXISTS_WITH Dyspnea
Subject
Disease
Predicate
COEXISTS_WITH
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Dyspnea
17. Disease COEXISTS_WITH Fever
Subject
Disease
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COEXISTS_WITH
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Fever
18. Nursing Homes LOCATION_OF Administration occupational activities
Subject
Nursing Homes
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LOCATION_OF
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Administration occupational activities
ABSTRACT

INTRODUCTION:

Since the start of the pandemic, millions of people have been infected, with thousands of deaths. Many foci worldwide have been identified in retirement nursing homes, with a high number of deaths. Our study aims were to evaluate the spread of SARS-CoV-2 in the retirement nursing homes, the predictors to develop symptoms, and death. METHODS AND

FINDINGS:

We conducted a retrospective study enrolling all people living in retirement nursing homes (PLRNH), where at least one SARS-CoV-2 infected person was present. Medical and clinical data were collected. Variables were compared with Student's t-test or Pearson chi-square test as appropriate. Uni- and multivariate analyses were conducted to evaluate variables' influence on infection and symptoms development. Cox proportional-hazards model was used to evaluate 30 days mortality predictors, considering death as the dependent variable. We enrolled 382 subjects. The mean age was 81.15±10.97 years, and males were 140(36.7%). At the multivariate analysis, mental disorders, malignancies, and angiotensin II receptor blockers were predictors of SARS-CoV-2 infection while having a neurological syndrome was associated with a lower risk. Only half of the people with SARS-CoV-2 infection developed symptoms. Chronic obstructive pulmonary disease and neurological syndrome were correlated with an increased risk of developing SARS-CoV-2 related symptoms. Fifty-six (21.2%) people with SARS-CoV-2 infection died; of these, 53 died in the first 30 days after the swab's positivity. Significant factors associated with 30-days mortality were male gender, hypokinetic disease, and the presence of fever and dyspnea. Patients' autonomy and early heparin treatment were related to lower mortality risk.

CONCLUSIONS:

We evidenced factors associated with infection's risk and death in a setting with high mortality such as retirement nursing homes, that should be carefully considered in the management of PLRNH.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study / Risk factors Topics: Long Covid Limits: Aged / Female / Humans / Male Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0248009

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study / Risk factors Topics: Long Covid Limits: Aged / Female / Humans / Male Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0248009