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Whole genome and phylogenetic analysis of two SARS-CoV-2 strains isolated in Italy in January and February 2020: additional clues on multiple introductions and further circulation in Europe.
Stefanelli, Paola; Faggioni, Giovanni; Lo Presti, Alessandra; Fiore, Stefano; Marchi, Antonella; Benedetti, Eleonora; Fabiani, Concetta; Anselmo, Anna; Ciammaruconi, Andrea; Fortunato, Antonella; De Santis, Riccardo; Fillo, Silvia; Capobianchi, Maria Rosaria; Gismondo, Maria Rita; Ciervo, Alessandra; Rezza, Giovanni; Castrucci, Maria Rita; Lista, Florigio.
  • Stefanelli P; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Faggioni G; Scientific Department Army Medical Center, Rome, Italy.
  • Lo Presti A; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Fiore S; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Marchi A; These authors contributed equally to the work.
  • Benedetti E; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Fabiani C; These authors contributed equally to the work.
  • Anselmo A; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Ciammaruconi A; These authors contributed equally to the work.
  • Fortunato A; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • De Santis R; These authors contributed equally to the work.
  • Fillo S; Scientific Department Army Medical Center, Rome, Italy.
  • Capobianchi MR; Scientific Department Army Medical Center, Rome, Italy.
  • Gismondo MR; Scientific Department Army Medical Center, Rome, Italy.
  • Ciervo A; Scientific Department Army Medical Center, Rome, Italy.
  • Rezza G; Scientific Department Army Medical Center, Rome, Italy.
  • Castrucci MR; Laboratory of Virology, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Rome, Italy.
  • Lista F; Clinical Microbiology, Virology and Bioemergency, L. Sacco University Hospital, Milan, Italy.
Euro Surveill ; 25(13)2020 04.
Article in English | MEDLINE | ID: covidwho-1389098
ABSTRACT
Whole genome sequences of SARS-CoV-2 obtained from two patients, a Chinese tourist visiting Rome and an Italian, were compared with sequences from Europe and elsewhere. In a phylogenetic tree, the Italian patient's sequence clustered with sequences from Germany while the tourist's sequence clustered with other European sequences. Some additional European sequences in the tree segregated outside the two clusters containing the patients' sequences. This suggests multiple SARS-CoV-2 introductions in Europe or virus evolution during circulation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Travel / RNA, Viral / Genome, Viral / Coronavirus Infections / Coronavirus / Severe Acute Respiratory Syndrome / Betacoronavirus / Whole Genome Sequencing Type of study: Diagnostic study / Observational study / Randomized controlled trials Limits: Humans Country/Region as subject: Asia / Europa Language: English Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: 1560-7917.ES.2020.25.13.2000305

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Travel / RNA, Viral / Genome, Viral / Coronavirus Infections / Coronavirus / Severe Acute Respiratory Syndrome / Betacoronavirus / Whole Genome Sequencing Type of study: Diagnostic study / Observational study / Randomized controlled trials Limits: Humans Country/Region as subject: Asia / Europa Language: English Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: 1560-7917.ES.2020.25.13.2000305