SARS-CoV-2 Pathogenesis: Imbalance in the Renin-Angiotensin System Favors Lung Fibrosis.

Delpino, M Victoria; Quarleri, Jorge

Delpino, M Victoria; Quarleri, Jorge.

Delpino MV; Facultad de Farmacia y Bioquímica, Instituto de Inmunología, Genética y Metabolismo (INIGEM), Universidad de Buenos Aires, Buenos Aires, Argentina.
Quarleri J; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.

Front Cell Infect Microbiol ; 10: 340, 2020.

Article in English | MEDLINE | ID: covidwho-1389151

Subject(s)

Betacoronavirus/pathogenicity; Coronavirus Infections/complications; Coronavirus Infections/virology; Peptidyl-Dipeptidase A/metabolism; Pneumonia, Viral/complications; Pneumonia, Viral/virology; Pulmonary Fibrosis/etiology; Renin-Angiotensin System/physiology; Alveolar Epithelial Cells/enzymology; Angiotensin I/metabolism; Angiotensin I/pharmacology; Angiotensin II/metabolism; Angiotensin-Converting Enzyme 2; Betacoronavirus/physiology; COVID-19; Coronavirus Infections/physiopathology; Host Microbial Interactions; Humans; Lung/enzymology; Lung/physiopathology; Lung/virology; Pandemics; Peptide Fragments/metabolism; Peptide Fragments/pharmacology; Peptidyl-Dipeptidase A/genetics; Pneumonia, Viral/physiopathology; Receptors, Coronavirus; Receptors, Virus/genetics; Receptors, Virus/metabolism; SARS-CoV-2; Transforming Growth Factor beta/antagonists & inhibitors; Transforming Growth Factor beta/metabolism

Keywords

ACE2; ANG1-7; Fibrosis; Renin angiotensin system (RAS); SARS-CoV-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pulmonary Fibrosis / Renin-Angiotensin System / Coronavirus Infections / Peptidyl-Dipeptidase A / Betacoronavirus Topics: Long Covid Limits: Humans Language: English Journal: Front Cell Infect Microbiol Year: 2020 Document Type: Article Affiliation country: FCIMB.2020.00340

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