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Risk of Environmental Exposure to H7N9 Influenza Virus via Airborne and Surface Routes in a Live Poultry Market in Hebei, China.
Zhang, Cheng; Guo, Kangkang; Cui, Huan; Chen, Ligong; Zhang, Chunmao; Wang, Xuejing; Li, Jiaming; Fu, Yingying; Wang, Zhongyi; Guo, Zhendong; Liu, Juxiang; Dong, Shishan.
  • Zhang C; College of Veterinary Medicine, Hebei Agricultural University, Baoding, China.
  • Guo K; Changchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun, China.
  • Cui H; College of Veterinary Medicine, Hebei Agricultural University, Baoding, China.
  • Chen L; Changchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun, China.
  • Zhang C; Changchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun, China.
  • Wang X; College of Animal Medicine, Jilin University, Changcchun, China.
  • Li J; College of Veterinary Medicine, Hebei Agricultural University, Baoding, China.
  • Fu Y; Changchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun, China.
  • Wang Z; College of Veterinary Medicine, Hebei Agricultural University, Baoding, China.
  • Guo Z; Beijing Institute of Biotechnology, Beijing, China.
  • Liu J; Beijing Institute of Biotechnology, Beijing, China.
  • Dong S; Beijing Institute of Biotechnology, Beijing, China.
Front Cell Infect Microbiol ; 11: 688007, 2021.
Article in English | MEDLINE | ID: covidwho-1389153
ABSTRACT
Environmental transmission of viruses to humans has become an early warning for potential epidemic outbreaks, such as SARS-CoV-2 and influenza virus outbreaks. Recently, an H7N9 virus, A/environment/Hebei/621/2019 (H7N9), was isolated by environmental swabs from a live poultry market in Hebei, China. We found that this isolate could be transmitted by direct contact and aerosol in mammals. More importantly, after 5 passages in mice, the virus acquired two adaptive mutations, PB1-H115Q and B2-E627K, exhibiting increased virulence and aerosol transmissibility. These results suggest that this H7N9 virus might potentially be transmitted between humans through environmental or airborne routes.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Environmental Exposure / Influenza, Human / Influenza A Virus, H7N9 Subtype / Influenza in Birds Type of study: Observational study / Prognostic study Limits: Animals / Humans Country/Region as subject: Asia Language: English Journal: Front Cell Infect Microbiol Year: 2021 Document Type: Article Affiliation country: FCIMB.2021.688007

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Environmental Exposure / Influenza, Human / Influenza A Virus, H7N9 Subtype / Influenza in Birds Type of study: Observational study / Prognostic study Limits: Animals / Humans Country/Region as subject: Asia Language: English Journal: Front Cell Infect Microbiol Year: 2021 Document Type: Article Affiliation country: FCIMB.2021.688007