Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report.
Front Immunol
; 11: 603428, 2020.
Article
in English
| MEDLINE | ID: covidwho-1389167
ABSTRACT
In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and experienced a mild course of infection, with limited inflammatory complications, despite pre-gene therapy clinical phenotype.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Wiskott-Aldrich Syndrome
/
Genetic Therapy
/
Antibodies, Neutralizing
/
SARS-CoV-2
/
COVID-19
/
Antibodies, Viral
Type of study:
Case report
/
Prognostic study
Limits:
Humans
/
Infant
/
Male
Language:
English
Journal:
Front Immunol
Year:
2020
Document Type:
Article
Affiliation country:
FIMMU.2020.603428
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