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Case Report: Convalescent Plasma Achieves SARS-CoV-2 Viral Clearance in a Patient With Persistently High Viral Replication Over 8 Weeks Due to Severe Combined Immunodeficiency (SCID) and Graft Failure.
Keitel, Verena; Bode, Johannes Georg; Feldt, Torsten; Walker, Andreas; Müller, Lisa; Kunstein, Anselm; Klindt, Caroline; Killer, Alexander; Senff, Tina; Timm, Jörg; Ostermann, Philipp; Damagnez, Maximilian; Lübke, Nadine; Adams, Ortwin; Schaal, Heiner; Antoch, Gerald; Neubert, Jennifer; Albrecht, Philipp; Meuth, Sven; Elben, Saskia; Mohring, Annemarie; Fischer, Johannes C; Bölke, Edwin; Hoenig, Manfred; Schulz, Ansgar S; Luedde, Tom; Jensen, Björn.
  • Keitel V; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Bode JG; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Feldt T; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Walker A; Institute of Virology, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Müller L; Institute of Virology, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Kunstein A; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Klindt C; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Killer A; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Senff T; Institute of Virology, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Timm J; Institute of Virology, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Ostermann P; Institute of Virology, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Damagnez M; Institute of Virology, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Lübke N; Institute of Virology, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Adams O; Institute of Virology, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Schaal H; Institute of Virology, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Antoch G; Department of Diagnostic and Interventional Radiology, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Neubert J; Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Albrecht P; Department of Neurology, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Meuth S; Department of Neurology, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Elben S; Department of Neurology, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Mohring A; Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Fischer JC; Institute for Transplant Diagnostics and Cell Therapeutics, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.
  • Bölke E; Department of Radiation Oncology, University Hospital Duesseldorf, Medical Faculty Heinrich-Heine-University, Duesseldorf, Germany.
  • Hoenig M; Pediatric Stem Cell Transplantation Unit, University Hospital Ulm, Ulm, Germany.
  • Schulz AS; Pediatric Stem Cell Transplantation Unit, University Hospital Ulm, Ulm, Germany.
  • Luedde T; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
  • Jensen B; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
Front Immunol ; 12: 645989, 2021.
Article in English | MEDLINE | ID: covidwho-1389177
ABSTRACT
We describe the unique disease course and cure of SARS-CoV-2 infection in a patient with SCID and graft failure. In absence of a humoral immune response, viral clearance was only achieved after transfusion of convalescent plasma. This observation underscores the necessity of the humoral immune response for SARS-CoV-2 clearance.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severe Combined Immunodeficiency / SARS-CoV-2 / COVID-19 Type of study: Case report / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: FIMMU.2021.645989

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severe Combined Immunodeficiency / SARS-CoV-2 / COVID-19 Type of study: Case report / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: FIMMU.2021.645989