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Evaluating SARS-CoV-2 Seroconversion Following Relieve of Confinement Measures.
Gonçalves, Juliana; Sousa, Rita L; Jacinto, Maria J; Silva, Daniela A; Paula, Filipe; Sousa, Rute; Zahedi, Sara; Carvalho, Joana; Cabral, M Guadalupe; Costa, Manuela; Branco, Jaime C; Canhão, Helena; Alves, José D; Rodrigues, Ana M; Soares, Helena.
  • Gonçalves J; Human Immunobiology and Pathogenesis Laboratory, Lisbon, Portugal.
  • Sousa RL; CEDOC-Chronic Diseases Research Center, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of Lisbon, Lisbon, Portugal.
  • Jacinto MJ; Human Immunobiology and Pathogenesis Laboratory, Lisbon, Portugal.
  • Silva DA; CEDOC-Chronic Diseases Research Center, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of Lisbon, Lisbon, Portugal.
  • Paula F; Católica-Lisbon School of Business and Economics, Catholic University of Portugal, Lisbon, Portugal.
  • Sousa R; Human Immunobiology and Pathogenesis Laboratory, Lisbon, Portugal.
  • Zahedi S; CEDOC-Chronic Diseases Research Center, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of Lisbon, Lisbon, Portugal.
  • Carvalho J; CEDOC-Chronic Diseases Research Center, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of Lisbon, Lisbon, Portugal.
  • Cabral MG; Internal Medicine Department IV/Immune Mediated Systemic Diseases (UDIMS), Fernando Fonseca Hospital, Amadora, Portugal.
  • Costa M; Immune Response and Vascular Disease Laboratory, Lisbon, Portugal.
  • Branco JC; Comprehensive Health Research Center (CHRC), NOVA Medical School, Lisbon, Portugal.
  • Canhão H; EpiDoC Unit, CEDOC, NOVA Medical School, UNL, Lisbon, Portugal.
  • Alves JD; CEDOC-Chronic Diseases Research Center, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of Lisbon, Lisbon, Portugal.
  • Rodrigues AM; Computational and Experimental Biology Laboratory, Lisbon, Portugal.
  • Soares H; Internal Medicine Department IV/Immune Mediated Systemic Diseases (UDIMS), Fernando Fonseca Hospital, Amadora, Portugal.
Front Med (Lausanne) ; 7: 603996, 2020.
Article in English | MEDLINE | ID: covidwho-1389195
ABSTRACT
Seroprevalence studies are crucial both for estimating the prevalence of SARS-CoV-2 exposure and to provide a measure for the efficiency of the confinement measures. Portuguese universities were closed on March 16th 2020, when Portugal only registered 62 SARS-CoV-2 infection cases per million. We have validated a SARS-CoV-2 ELISA assay to a stabilized full-length spike protein using 216 pre-pandemic and 19 molecularly diagnosed SARS-CoV-2 positive individual's samples. At NOVA University of Lisbon, presential work was partially resumed on May 25th with staggered schedules. From June 15th to 30th, 3-4 weeks after the easing of confinement measures, we screened 1,636 collaborators of NOVA university of Lisbon for the presence of SARS-CoV-2 spike specific IgA and IgG antibodies. We found that spike-specific IgG in 50 of 1,636 participants (3.0%), none of which had anti-spike IgA antibodies. As participants self-reported as asymptomatic or paucisymptomatic, our study also provides a measurement of the prevalence of asymptomatic/paucisymptomatic SARS-CoV-2 infections. Our study suggests that essential workers have a 2-fold increase in viral exposure, when compared to non-essential workers that observed confinement. Additional serological surveys in different population subgroups will paint a broader picture of the effect of the confinement measures in the broader community.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Language: English Journal: Front Med (Lausanne) Year: 2020 Document Type: Article Affiliation country: FMED.2020.603996

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Language: English Journal: Front Med (Lausanne) Year: 2020 Document Type: Article Affiliation country: FMED.2020.603996