SARS-CoV-2 Virion Stabilization by Zn Binding.
Front Mol Biosci
; 7: 222, 2020.
Article
in English
| MEDLINE | ID: covidwho-1389211
ABSTRACT
Zinc plays a crucial role in the process of virion maturation inside the host cell. The accessory Cys-rich proteins expressed in SARS-CoV-2 by genes ORF7a and ORF8 are likely involved in zinc binding and in interactions with cellular antigens activated by extensive disulfide bonds. In this report we provide a proof of concept for the feasibility of a structural study of orf7a and orf8 proteins. A conceivable hypothesis is that lack of cellular zinc, or substitution thereof, might lead to a significant slowing down of viral maturation.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Language:
English
Journal:
Front Mol Biosci
Year:
2020
Document Type:
Article
Affiliation country:
FMOLB.2020.00222
Similar
MEDLINE
...
LILACS
LIS