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Prioritizing the First Doses of SARS-CoV-2 Vaccine to Save the Elderly: The Case Study of Italy.
Pontrelli, Giuseppe; Cimini, Giulio; Roversi, Marco; Gabrielli, Andrea; Salina, Gaetano; Bernardi, Stefania; Rocchi, Francesca; Simonetti, Alessandra; Giaquinto, Carlo; Rossi, Paolo; Sylos Labini, Francesco.
  • Pontrelli G; Academic Department of Pediatrics, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
  • Cimini G; University of Tor Vergata, Rome, Italy.
  • Roversi M; Physics Department and Istituto Nazionale di Fisica Nucleare, University of Tor Vergata, Rome, Italy.
  • Gabrielli A; Enrico Fermi Research Center, Rome, Italy.
  • Salina G; Academic Department of Pediatrics, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
  • Bernardi S; University of Tor Vergata, Rome, Italy.
  • Rocchi F; Enrico Fermi Research Center, Rome, Italy.
  • Simonetti A; Engineering Department, Roma Tre University, Rome, Italy.
  • Giaquinto C; Physics Department and Istituto Nazionale di Fisica Nucleare, University of Tor Vergata, Rome, Italy.
  • Rossi P; Enrico Fermi Research Center, Rome, Italy.
  • Sylos Labini F; Academic Department of Pediatrics, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
Front Public Health ; 9: 684760, 2021.
Article in English | MEDLINE | ID: covidwho-1389258
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ABSTRACT
SARS-CoV-2 is currently causing hundreds of deaths every day in European countries, mostly in not yet vaccinated elderly. Vaccine shortage poses relevant challenges to health authorities, called to act promptly with a scarcity of data. We modeled the mortality reduction of the elderly according to a schedule of mRNA SARS-CoV-2 vaccine that prioritized first dose administration. For the case study of Italy, we show an increase in protected individuals up to 53.4% and a decrease in deaths up to 19.8% in the cohort of over 80's compared with the standard vaccine recalls after 3 or 4 weeks. This model supports the adoption of vaccination campaigns that prioritize the administration of the first doses in the elderly.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Case report / Cohort study / Observational study / Prognostic study Topics: Vaccines Limits: Aged / Humans Country/Region as subject: Europa Language: English Journal: Front Public Health Year: 2021 Document Type: Article Affiliation country: FPUBH.2021.684760

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Case report / Cohort study / Observational study / Prognostic study Topics: Vaccines Limits: Aged / Humans Country/Region as subject: Europa Language: English Journal: Front Public Health Year: 2021 Document Type: Article Affiliation country: FPUBH.2021.684760