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The Influence of Virus Infection on Microglia and Accelerated Brain Aging.
Filgueira, Luis; Larionov, Alexey; Lannes, Nils.
  • Filgueira L; Anatomy, Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland.
  • Larionov A; Anatomy, Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland.
  • Lannes N; Anatomy, Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland.
Cells ; 10(7)2021 07 20.
Article in English | MEDLINE | ID: covidwho-1389305
ABSTRACT
Microglia are the resident immune cells of the central nervous system contributing substantially to health and disease. There is increasing evidence that inflammatory microglia may induce or accelerate brain aging, by interfering with physiological repair and remodeling processes. Many viral infections affect the brain and interfere with microglia functions, including human immune deficiency virus, flaviviruses, SARS-CoV-2, influenza, and human herpes viruses. Especially chronic viral infections causing low-grade neuroinflammation may contribute to brain aging. This review elucidates the potential role of various neurotropic viruses in microglia-driven neurocognitive deficiencies and possibly accelerated brain aging.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain / Virus Diseases / Aging / Microglia / Inflammation Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: CELLS10071836

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain / Virus Diseases / Aging / Microglia / Inflammation Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: CELLS10071836