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Expression Pattern of the SARS-CoV-2 Entry Genes ACE2 and TMPRSS2 in the Respiratory Tract.
Liu, Yichuan; Qu, Hui-Qi; Qu, Jingchun; Tian, Lifeng; Hakonarson, Hakon.
  • Liu Y; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Qu HQ; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Qu J; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Tian L; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Hakonarson H; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Viruses ; 12(10)2020 10 16.
Article in English | MEDLINE | ID: covidwho-1389518
ABSTRACT
To address the expression pattern of the SARS-CoV-2 receptor ACE2 and the viral priming protease TMPRSS2 in the respiratory tract, this study investigated RNA sequencing transcriptome profiling of samples of airway and oral mucosa. As shown, ACE2 has medium levels of expression in both small airway epithelium and masticatory mucosa, and high levels of expression in nasal epithelium. The expression of ACE2 is low in mucosal-associated invariant T (MAIT) cells and cannot be detected in alveolar macrophages. TMPRSS2 is highly expressed in small airway epithelium and nasal epithelium and has lower expression in masticatory mucosa. Our results provide the molecular basis that the nasal mucosa is the most susceptible locus in the respiratory tract for SARS-CoV-2 infection and consequently for subsequent droplet transmission and should be the focus for protection against SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Serine Endopeptidases / Coronavirus Infections / Peptidyl-Dipeptidase A / Virus Internalization / Betacoronavirus Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: V12101174

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Serine Endopeptidases / Coronavirus Infections / Peptidyl-Dipeptidase A / Virus Internalization / Betacoronavirus Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: V12101174