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The Latest Achievements in the Construction of Influenza Virus Detection Aptasensors.
Wedrowska, Ewelina; Wandtke, Tomasz; Piskorska, Elzbieta; Kopinski, Piotr.
  • Wedrowska E; Department of Lung Diseases, Neoplasms and Tuberculosis, Faculty of Medicine, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland.
  • Wandtke T; Department of Lung Diseases, Neoplasms and Tuberculosis, Faculty of Medicine, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland.
  • Piskorska E; Department of Pathobiochemistry and Clinical Chemistry, Faculty of Pharmacy, Nicolaus Copernicus University Collegium Medicum, 85-094 Bydgoszcz, Poland.
  • Kopinski P; Department of Lung Diseases, Neoplasms and Tuberculosis, Faculty of Medicine, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland.
Viruses ; 12(12)2020 11 30.
Article in English | MEDLINE | ID: covidwho-1389520
ABSTRACT
Aptamers are short fragments of nucleic acids, DNA or RNA that have the ability to bind selected proteins with high specificity and affinity. These properties allow them to be used as an element of biosensors for the detection of specific proteins, including viral ones, which makes it possible to design valuable diagnostic tools. The influenza virus causes a huge number of human and animal deaths worldwide every year, and contributes to remarkable economic losses. In addition, in 2020, a new threat appeared-the SARS-Cov-2 pandemic. Both disease entities, especially in the initial stage of infection, are almost identical in terms of signs and symptoms. Therefore, a diagnostic solution is needed that will allow distinguishing between both pathogens, with high sensitivity and specificity; it should be cheap, quick and possible to use in the field, for example, in a doctor's office. All the mentioned properties are met by aptasensors in which the detection elements are specific aptamers. We present here the latest developments in the construction of various types of aptasensors for the detection of influenza virus. Aptasensor operation is based on the measurement of changes in electric impedance, fluorescence or electric signal (impedimetric, fluorescence and electrochemical aptasensors, respectively); it allows both qualitative and quantitative determinations. The particularly high advancement for detecting of influenza virus concerns impedimetric aptasensors.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Orthomyxoviridae / Biosensing Techniques / Aptamers, Nucleotide / Influenza, Human Type of study: Diagnostic study / Qualitative research Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: V12121365

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Orthomyxoviridae / Biosensing Techniques / Aptamers, Nucleotide / Influenza, Human Type of study: Diagnostic study / Qualitative research Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: V12121365