Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans.

Cagigi, Alberto; Loré, Karin

Cagigi, Alberto; Loré, Karin.

Cagigi A; Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, 161 64 Solna, Sweden.
Loré K; Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, 161 64 Solna, Sweden.

Vaccines (Basel) ; 9(1)2021 Jan 18.

Article in English | MEDLINE | ID: covidwho-1389565

ABSTRACT

ABSTRACT

In this concise review, we summarize the concepts behind mRNA vaccination. We discuss the innate and adaptive immune response generated by mRNA vaccines in different animal models and in humans. We give examples of viral infections where mRNA vaccines have shown to induce potent responses and we discuss in more detail the recent SARS-CoV-2 mRNA vaccine trials in humans.

Keywords

SARS-CoV-2; Th1 polarization; antibody response; dendritic cell; mRNA vaccine; protein translation; type I interferon

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: VACCINES9010061

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