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Antibody Responses to SARS-CoV-2 mRNA Vaccines Are Detectable in Saliva.
Ketas, Thomas J; Chaturbhuj, Devidas; Portillo, Victor M Cruz; Francomano, Erik; Golden, Encouse; Chandrasekhar, Sharanya; Debnath, Gargi; Díaz-Tapia, Randy; Yasmeen, Anila; Kramer, Kyle D; Munawar, Tarek; Leconet, Wilhelm; Zhao, Zhen; Brouwer, Philip J M; Cushing, Melissa M; Sanders, Rogier W; Cupo, Albert; Klasse, Per Johan; Formenti, Silvia C; Moore, John P.
  • Ketas TJ; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York.
  • Chaturbhuj D; TJK and DC made equal contributions to this paper.
  • Portillo VMC; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York.
  • Francomano E; TJK and DC made equal contributions to this paper.
  • Golden E; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York.
  • Chandrasekhar S; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York.
  • Debnath G; Department of Radiation Oncology, Weill Cornell Medicine, New York, New York.
  • Díaz-Tapia R; Department of Radiation Oncology, Weill Cornell Medicine, New York, New York.
  • Yasmeen A; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York.
  • Kramer KD; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York.
  • Munawar T; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York.
  • Leconet W; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York.
  • Zhao Z; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York.
  • Brouwer PJM; Department of Urology, Weill Cornell Medicine, New York, New York.
  • Cushing MM; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York.
  • Sanders RW; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Infection & Immunity Institute, Amsterdam, the Netherlands.
  • Cupo A; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York.
  • Klasse PJ; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York.
  • Formenti SC; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Infection & Immunity Institute, Amsterdam, the Netherlands.
  • Moore JP; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York.
Pathog Immun ; 6(1): 116-134, 2021.
Article in English | MEDLINE | ID: covidwho-1389907
ABSTRACT
The approved Pfizer and Moderna mRNA vaccines are well known to induce serum antibody responses to the SARS-CoV-2 Spike (S)-protein. However, their abilities to elicit mucosal immune responses have not been reported. Saliva antibodies represent mucosal responses that may be relevant to how mRNA vaccines prevent oral and nasal SARS-CoV-2 transmission. Here, we describe the outcome of a cross-sectional study on a healthcare worker cohort (WELCOME-NYPH), in which we assessed whether IgM, IgG, and IgA antibodies to the S-protein and its receptor-binding domain (RBD) were present in serum and saliva samples. Anti-S-protein IgG was detected in 14/31 and 66/66 of saliva samples from uninfected participants after vaccine doses-1 and -2, respectively. IgA antibodies to the S-protein were present in 40/66 saliva samples after dose 2. Anti-S-protein IgG was present in every serum sample from recipients of 2 vaccine doses. Vaccine-induced antibodies against the RBD were also frequently present in saliva and sera. These findings may help our understanding of whether and how vaccines may impede SARS-CoV-2 transmission, including to oral cavity target cells.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Language: English Journal: Pathog Immun Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Language: English Journal: Pathog Immun Year: 2021 Document Type: Article