A Septic Shock and Multi-Organ-Failure Case due to Mediterranean Spotted Fever

ABSTRACT

Introduction Mediterranean spotted fever (MSF) is a zoonotic disease caused by Rickettsia conorii, an obligate intracellular gram-negative bacteria [1]. While blood chemistry tests showed neutrophilic leukocytosis (white blood cells 18.090 mm3 with 95% neutrophils), thrombocytopenia (platelet count 79.000 mm3), creatinine 1.3 mg/ dl;values in the normal range of PT, PTT, fibrinogen, antithrombin III, transaminases and bilirubin;increase in inflammation index with C-Reactive Protein 250 mg/L (normal value <5 mg/L) and procalcitonin 14.4 ng/ml (normal value <0.5 ng/ml). According to the guidelines of the Italian Society of Tropical Diseases, treatment of MSF is doxicicline 100 mg os q12h for 10 days [16]. [...]Mediterranean Spotted Fever is a disease that can have different clinical pictures from benign pictures to really serious manifestations.