The Significance of Oral Fluid Antigen Rapid Test in the Time of the COVID-19 Epidemic

ABSTRACT

Other infected patients have mild or severe symptoms and may be life-threatening. [...]there is giant demand for the COVID-19 rapid tests. In samples without infected, since there is no target gene amplification, no increase in fluorescence signal would be detected. [...]nucleic acid detection is actually to determine whether there is novel coronavirus nucleic acid in the sample by detecting the accumulation of fluorescent signals. According to the principle of doubleantibody sandwich ELISA, using two antigen-specific antibodies to recognize and bind to different epitopes of a target antigen can greatly reduce the probability of cross-reaction, thereby effectively improving its specificity [1]. Positive detection of IgG in blood can be used as an indicator of infection and previous infection [8]. [...]an increase of IgM antibody indicates a recent acute infection, and an increase of IgG antibody indicates a previous infection.