Antivirals with common targets against highly pathogenic viruses.
Cell
; 184(6): 1604-1620, 2021 03 18.
Article
in English
| MEDLINE | ID: covidwho-1392179
ABSTRACT
Historically, emerging viruses appear constantly and have cost millions of human lives. Currently, climate change and intense globalization have created favorable conditions for viral transmission. Therefore, effective antivirals, especially those targeting the conserved protein in multiple unrelated viruses, such as the compounds targeting RNA-dependent RNA polymerase, are urgently needed to combat more emerging and re-emerging viruses in the future. Here we reviewed the development of antivirals with common targets, including those against the same protein across viruses, or the same viral function, to provide clues for development of antivirals for future epidemics.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Viruses
/
Virus Diseases
/
Communicable Diseases, Emerging
/
Molecular Targeted Therapy
/
Pandemics
Type of study:
Observational study
Limits:
Animals
/
Humans
Language:
English
Journal:
Cell
Year:
2021
Document Type:
Article
Affiliation country:
J.cell.2021.02.013
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