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Antivirals with common targets against highly pathogenic viruses.
Lu, Lu; Su, Shan; Yang, Haitao; Jiang, Shibo.
  • Lu L; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China.
  • Su S; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China.
  • Yang H; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, Shanghai Tech University, Shanghai 201210, China. Electronic address: yanght@shanghaitech.edu.cn.
  • Jiang S; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China. Electronic address: shibojiang@fudan.edu.cn.
Cell ; 184(6): 1604-1620, 2021 03 18.
Article in English | MEDLINE | ID: covidwho-1392179
ABSTRACT
Historically, emerging viruses appear constantly and have cost millions of human lives. Currently, climate change and intense globalization have created favorable conditions for viral transmission. Therefore, effective antivirals, especially those targeting the conserved protein in multiple unrelated viruses, such as the compounds targeting RNA-dependent RNA polymerase, are urgently needed to combat more emerging and re-emerging viruses in the future. Here we reviewed the development of antivirals with common targets, including those against the same protein across viruses, or the same viral function, to provide clues for development of antivirals for future epidemics.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Viruses / Virus Diseases / Communicable Diseases, Emerging / Molecular Targeted Therapy / Pandemics Type of study: Observational study Limits: Animals / Humans Language: English Journal: Cell Year: 2021 Document Type: Article Affiliation country: J.cell.2021.02.013

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Viruses / Virus Diseases / Communicable Diseases, Emerging / Molecular Targeted Therapy / Pandemics Type of study: Observational study Limits: Animals / Humans Language: English Journal: Cell Year: 2021 Document Type: Article Affiliation country: J.cell.2021.02.013