SARS-CoV-2 Variants Are Selecting for Spike Protein Mutations That Increase Protein Stability.

Shorthouse, David; Hall, Benjamin A

Shorthouse, David; Hall, Benjamin A.

Shorthouse D; Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom WC1E 6BT.
Hall BA; Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom WC1E 6BT.

J Chem Inf Model ; 61(9): 4152-4155, 2021 09 27.

Article in English | MEDLINE | ID: covidwho-1392764

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ABSTRACT

ABSTRACT

The emergence of variants of SARS-CoV-2 with mutations in their spike protein are a major cause for concern for the efficacy of vaccines and control of the pandemic. We show that mutations in the spike protein of SARS-CoV-2 are selecting for amino acid changes that result in a more thermodynamically stable protein than expected from background. We suggest that the computationally efficient analysis of mutational stability may aid in early screening of variants.

Subject(s)

COVID-19; SARS-CoV-2; Humans; Mutation; Protein Stability; Spike Glycoprotein, Coronavirus/genetics

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Journal: J Chem Inf Model Journal subject: Medical Informatics / Chemistry Year: 2021 Document Type: Article

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