A meta-analysis reveals the effectiveness of probiotics and prebiotics against respiratory viral infection.
Biosci Rep
; 41(3)2021 03 26.
Article
in English
| MEDLINE | ID: covidwho-1392910
ABSTRACT
Experimental experience suggests that microbial agents including probiotics and prebiotics (representative microbial agents) play a critical role in defending against respiratory virus infection. We aim to systematically examine these agents' effect on respiratory viral infection and encourage research into clinical applications. An electronic literature search was conducted from published data with a combination of a microbial agents search component containing synonyms for microbial agents-related terms and a customized search component for respiratory virus infection. Hazard ratio (HR), risk ratio (RR) and standard deviation (SD) were employed as effect estimates. In 45 preclinical studies, the mortality rates decreased in the respiratory viral infection models that included prebiotics or prebiotics as interventions (HR 0.70; 95% confidence interval (CI) 0.56-0.87; P=0.002). There was a significant decrease in viral load due to improved gut microbiota (SD -1.22; 95% CI -1.50 to -0.94; P<0.001). Concentrations of interferon (IFN)-α (SD 1.05; 95% CI 0.33-1.77; P=0.004), IFN-γ (SD 0.83; 95% CI 0.01-1.65; P=0.05) and interleukin (IL)-12 (SD 2.42; 95% CI 0.32-4.52; P=0.02), IL-1ß (SD 0.01; 95% CI -0.37 to 0.40; P=0.94) increased, whereas those of TNF-α (SD -0.58; 95% CI -1.59 to 0.43; P=0.26) and IL-6 (SD -0.59; 95% CI -1.24 to 0.07; P=0.08) decreased. Six clinical studies had lower symptom scores (SD -0.09; 95% CI -0.44 to 0.26; P=0.61) and less incidence of infection (RR 0.80; 95% CI 0.64-1.01; P=0.06). Our research indicates that probiotics and prebiotics pose a defensive possibility on respiratory viral infection and may encourage the clinical application.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Common Cold
/
Orthomyxoviridae Infections
/
Probiotics
/
Prebiotics
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Reviews
Limits:
Animals
/
Humans
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
BSR20203638
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