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Letter to the editor: COVID in patients with brain injury with a disorder of consciousness: a pathogenetic theory.
Comanducci, Angela; Viganò, Alessandro; Caronni, Antonio.
  • Comanducci A; IRCCS Fondazione Don Carlo Gnocchi Onlus, Milano, Italy.
  • Viganò A; IRCCS Fondazione Don Carlo Gnocchi Onlus, Milano, Italy.
  • Caronni A; IRCCS Fondazione Don Carlo Gnocchi Onlus, Milano, Italy.
Brain Inj ; 35(12-13): 1647-1648, 2021 11 10.
Article in English | MEDLINE | ID: covidwho-1393020
ABSTRACT
We recently published in this journal (Caronni and colleagues, Brain Injury, 2021-04-16) the first description of the spread of the SARS-CoV-2 infection in a cohort of brain injured patients with a disorder of consciousness (DOC). Surprisingly enough we showed that, in these patients, the COVID was moderate and did not result in fatalities. The pathogenesis of the COVID is characterized by the profound dysregulation of the immune system. To explain our findings, we speculated that the immunosuppression due to the brain injury could be protective against the development of the COVID in patients with DOC. More recently, a second group of authors (Marino and colleagues, PLoSOne, 2021-06-30) described the course of the COVID in an independent cohort of patients with DOC. Since our results were quite unexpected, we have been very comforted by the data reported by Marino and colleagues. Moreover, these data also offer a unique opportunity to further evaluate our theory regarding the COVID pathogenesis in patients with DOC. In the current Letter to the Editor it is shown that the independent data presented by Marino and colleagues do support our theory. Waiting for larger cohorts to further test it (and in case falsify it), our interpretation seems to remain valid.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain Injuries / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Brain Inj Journal subject: Brain Year: 2021 Document Type: Article Affiliation country: 02699052.2021.1972456

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain Injuries / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Brain Inj Journal subject: Brain Year: 2021 Document Type: Article Affiliation country: 02699052.2021.1972456