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TMEM41B and VMP1 are phospholipid scramblases.
Zhang, Tizhong; Li, Yang E; Yuan, Yiqiong; Du, Ximing; Wang, Yichang; Dong, Xiuju; Yang, Hongyuan; Qi, Shiqian.
  • Zhang T; Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, Chengdu, Sichuan, China.
  • Li YE; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.
  • Yuan Y; Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, Chengdu, Sichuan, China.
  • Du X; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.
  • Wang Y; Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, Chengdu, Sichuan, China.
  • Dong X; Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, Chengdu, Sichuan, China.
  • Yang H; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.
  • Qi S; Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, Chengdu, Sichuan, China.
Autophagy ; 17(8): 2048-2050, 2021 08.
Article in English | MEDLINE | ID: covidwho-1393103
ABSTRACT
TMEM41B and VMP1, two endoplasmic reticulum (ER)-resident transmembrane proteins, play important roles in regulating the formation of lipid droplets (LDs), autophagy initiation, and viral infection. However, the biochemical functions of TMEM41B and VMP1 are unclear. A lipids distribution screen suggested TMEM41B and VMP1 are critical to the normal distribution of cholesterol and phosphatidylserine. Biochemical analyses unveiled that TMEM41B and VMP1 have scramblase activity. These findings shed light on the mechanism by which TMEM41B and VMP1 regulate LD formation, lipids distribution, macroautophagy, and viral infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autophagy / Phospholipid Transfer Proteins / Membrane Proteins Limits: Animals / Humans Language: English Journal: Autophagy Year: 2021 Document Type: Article Affiliation country: 15548627.2021.1937898

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autophagy / Phospholipid Transfer Proteins / Membrane Proteins Limits: Animals / Humans Language: English Journal: Autophagy Year: 2021 Document Type: Article Affiliation country: 15548627.2021.1937898