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COVID-19 mRNA Vaccination Generates Greater Immunoglobulin G Levels in Women Compared to Men.
Demonbreun, Alexis R; Sancilio, Amelia; Velez, Matt E; Ryan, Daniel T; Pesce, Lorenzo; Saber, Rana; Vaught, Lauren A; Reiser, Nina L; Hsieh, Ryan R; D'Aquila, Richard T; Mustanski, Brian; McDade, Thomas W; McNally, Elizabeth M.
  • Demonbreun AR; Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Sancilio A; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Velez ME; Department of Anthropology and Institute for Policy Research, Northwestern University, Evanston, Illinois, USA.
  • Ryan DT; Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Pesce L; Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Saber R; Institute for Sexual and Gender Minority Health and Wellbeing, Chicago, Illinois, USA.
  • Vaught LA; Department of Medical Social Sciences, Northwestern University, Chicago, Illinois, USA.
  • Reiser NL; Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Hsieh RR; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • D'Aquila RT; Institute for Sexual and Gender Minority Health and Wellbeing, Chicago, Illinois, USA.
  • Mustanski B; Department of Medical Social Sciences, Northwestern University, Chicago, Illinois, USA.
  • McDade TW; Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • McNally EM; Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
J Infect Dis ; 224(5): 793-797, 2021 09 01.
Article in English | MEDLINE | ID: covidwho-1393272
ABSTRACT
We investigated whether the antibody response to coronavirus disease 2019 (COVID-19) mRNA vaccination is similar in women and men. In a community cohort without prior COVID-19, first vaccine dose produced higher immunoglobulin G (IgG) levels and percent inhibition of spike-ACE2 receptor binding, a surrogate measure of virus neutralization, in women compared to men (7.0 µg/mL, 51.6% vs 3.3 µg/mL, 36.4%). After 2 doses, IgG levels remained significantly higher for women (30.4 µg/mL) compared to men (20.6 µg/mL), while percent inhibition was similar (98.4% vs 97.7%). Sex-specific antibody response to mRNA vaccination informs future efforts to understand vaccine protection and side effects.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Vaccines, Synthetic / COVID-19 Vaccines / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Vaccines Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Vaccines, Synthetic / COVID-19 Vaccines / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Vaccines Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis