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COVID-19 susceptibility variants associate with blood clots, thrombophlebitis and circulatory diseases.
Papadopoulou, Areti; Musa, Hanan; Sivaganesan, Mathura; McCoy, David; Deloukas, Panos; Marouli, Eirini.
  • Papadopoulou A; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
  • Musa H; Centre for Genomic Health, Life Sciences, Queen Mary University of London, London, United Kingdom.
  • Sivaganesan M; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
  • McCoy D; Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom.
  • Deloukas P; Population Health Sciences, Queen Mary University of London, London, United Kingdom.
  • Marouli E; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
PLoS One ; 16(9): e0256988, 2021.
Article in English | MEDLINE | ID: covidwho-1394552
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ABSTRACT
Epidemiological studies suggest that individuals with comorbid conditions including diabetes, chronic lung, inflammatory and vascular disease, are at higher risk of adverse COVID-19 outcomes. Genome-wide association studies have identified several loci associated with increased susceptibility and severity for COVID-19. However, it is not clear whether these associations are genetically determined or not. We used a Phenome-Wide Association (PheWAS) approach to investigate the role of genetically determined COVID-19 susceptibility on disease related outcomes. PheWAS analyses were performed in order to identify traits and diseases related to COVID-19 susceptibility and severity, evaluated through a predictive COVID-19 risk score. We utilised phenotypic data in up to 400,000 individuals from the UK Biobank, including Hospital Episode Statistics and General Practice data. We identified a spectrum of associations between both genetically determined COVID-19 susceptibility and severity with a number of traits. COVID-19 risk was associated with increased risk for phlebitis and thrombophlebitis (OR = 1.11, p = 5.36e-08). We also identified significant signals between COVID-19 susceptibility with blood clots in the leg (OR = 1.1, p = 1.66e-16) and with increased risk for blood clots in the lung (OR = 1.12, p = 1.45 e-10). Our study identifies significant association of genetically determined COVID-19 with increased blood clot events in leg and lungs. The reported associations between both COVID-19 susceptibility and severity and other diseases adds to the identification and stratification of individuals at increased risk, adverse outcomes and long-term effects.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombophlebitis / Thrombosis / COVID-19 / Obesity Type of study: Experimental Studies / Observational study / Prognostic study Topics: Variants Limits: Female / Humans / Male Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0256988

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombophlebitis / Thrombosis / COVID-19 / Obesity Type of study: Experimental Studies / Observational study / Prognostic study Topics: Variants Limits: Female / Humans / Male Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0256988