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Coronaviruses and Endocrine System: A Systematic Review on Evidence and Shadows.
Parolin, Matteo; Parisotto, Matteo; Zanchetta, Francesca; Sartorato, Paola; De Menis, Ernesto.
  • Parolin M; Internal Medicine 2, Ca' Foncello Hospital, ULSS2 Marca Trevigiana, Treviso, Italy.
  • Parisotto M; Department of Medicine- DIMED, University of Padova, Padova, Italy.
  • Zanchetta F; Department of Medicine- DIMED, University of Padova, Padova, Italy.
  • Sartorato P; Ospedale San Valentino, ULSS2 Marca Trevigiana, Montebelluna (TV), Italy.
  • De Menis E; Internal Medicine 2, Ca' Foncello Hospital, ULSS2 Marca Trevigiana, Treviso, Italy.
Endocr Metab Immune Disord Drug Targets ; 21(7): 1242-1251, 2021.
Article in English | MEDLINE | ID: covidwho-1394672
Semantic information from SemMedBD (by NLM)
1. Human coronavirus INTERACTS_WITH 2019 novel coronavirus
Subject
Human coronavirus
Predicate
INTERACTS_WITH
Object
2019 novel coronavirus
2. angiotensin converting enzyme 2 AFFECTS Organ
Subject
angiotensin converting enzyme 2
Predicate
AFFECTS
Object
Organ
3. Severe Acute Respiratory Syndrome PROCESS_OF Patients
Subject
Severe Acute Respiratory Syndrome
Predicate
PROCESS_OF
Object
Patients
4. Human coronavirus INTERACTS_WITH 2019 novel coronavirus
Subject
Human coronavirus
Predicate
INTERACTS_WITH
Object
2019 novel coronavirus
5. angiotensin converting enzyme 2 AFFECTS Organ
Subject
angiotensin converting enzyme 2
Predicate
AFFECTS
Object
Organ
6. Severe Acute Respiratory Syndrome PROCESS_OF Patients
Subject
Severe Acute Respiratory Syndrome
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
Coronaviruses are a big family of viruses that can infect mammalians and birds. In humans they mainly cause respiratory tract infections, with a large spectrum of severity, from mild, self-limited infections to highly lethal forms as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and Coronavirus Disease 2019 (COVID-19). Scanty data are reported for the involvement of endocrine glands in human coronaviruses, in particular SARS-CoV-2. In this review, we summarize endocrinological involvement in human coronaviruses, including data on animal coronaviruses. Avians, ferrets and bovine are affected by specific coronavirus syndromes, with variable involvement of endocrine glands. SARS-CoV and SARS-CoV-2 use angiotensin-converting enzyme 2 (ACE2) as a target receptor, so ACE2 plays a central role in viral transmission and initial organ involvement. Autoptic studies on SARS patients revealed that thyroid, parathyroid, pituitary gland, endocrine pancreas and especially adrenals and testis could be impaired by different mechanisms (direct damage by SARS-CoV, inflammation, vascular derangement and autoimmune reactions) and few clinical studies have evidenced functional endocrine impairment. Only few data are available for COVID-19 and gonads and endocrine pancreas seem to be involved. International endocrinological societies have brought some recommendations for the COVID-19 pandemic, but further studies need to be performed, especially to detect long-term hormonal sequelae.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endocrine System Diseases / Endocrine Glands / Middle East Respiratory Syndrome Coronavirus / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Animals / Humans Language: English Journal: Endocr Metab Immune Disord Drug Targets Journal subject: Allergy and Immunology / Endocrinology / Metabolism / Drug Therapy Year: 2021 Document Type: Article Affiliation country: 1871530320666200905123332

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endocrine System Diseases / Endocrine Glands / Middle East Respiratory Syndrome Coronavirus / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Animals / Humans Language: English Journal: Endocr Metab Immune Disord Drug Targets Journal subject: Allergy and Immunology / Endocrinology / Metabolism / Drug Therapy Year: 2021 Document Type: Article Affiliation country: 1871530320666200905123332