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Coronavirus disease 2019 in solid organ transplant recipients in the setting of proactive screening and contact tracing of Qatar.
Alattar, Rand A; Shaar, Shahd H; Othman, Muftah; Abu Jarir, Sulieman H; Hashim, Samar M; Iqbal, Fatima; Rustom, Fatima; Almaslamani, Muna A; Omrani, Ali S.
  • Alattar RA; Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar.
  • Shaar SH; Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar.
  • Othman M; Division of Nephrology, Hamad Medical Corporation, Doha, Qatar.
  • Abu Jarir SH; Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar.
  • Hashim SM; Division of Infectious Diseases, Hamad Medical Corporation, Doha, Qatar.
  • Iqbal F; Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar.
  • Rustom F; Division of Infectious Diseases, Hamad Medical Corporation, Doha, Qatar.
  • Almaslamani MA; Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar.
  • Omrani AS; Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar.
Qatar Med J ; 2021(2): 23, 2021.
Article in English | MEDLINE | ID: covidwho-1395193
ABSTRACT

BACKGROUND:

Clinical data on Coronavirus Disease 2019 (COVID-19) in solid organ transplant (SOT) recipients are limited. We herein report the initial clinical experience with COVID-19 in SOT recipients in Qatar.

METHODS:

All SOT recipients with laboratory-confirmed COVID-19 up to May 23, 2020 were included. Demographic and clinical data were extracted retrospectively from the hospital's electronic health records. Categorical data are presented as frequency and percentages, while continuous variables are summarized as medians and ranges.

RESULTS:

Twenty-four SOT recipients with COVID-19 were identified (kidney 16, liver 6, heart 1, and liver and kidney 1). Organ transplantation preceded COVID-19 by a median of 60 months (range 1.7-184). The median age was 57 years (range 24-72), and 9 (37.5%) transplant recipients were females. Five (21%) asymptomatic patients were diagnosed through proactive screening. For the rest, fever (15/19) and cough (13/19) were the most frequent presenting symptoms. Five (20.8%) patients required invasive mechanical ventilation in the intensive care unit (ICU). Eleven (46%) patients developed acute kidney injury, including three in association with drug-drug interactions involving investigational COVID-19 therapies. Maintenance immunosuppressive therapy was modified in 18 (75%) patients, but systemic corticosteroids were not discontinued in any. After a median follow-up of 226 days (26-272), 20 (83.3%) patients had been discharged home, 2 (8.3%) were still hospitalized, 1 (4.2%) was still in the ICU, and 1 (4.2%) had died.

CONCLUSIONS:

Our results suggest that asymptomatic COVID-19 is possible in SOT recipients and that overall outcomes are not uniformly worse than those in the general population. The results require confirmation in large, international cohorts.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Prognostic study / Screening study Language: English Journal: Qatar Med J Year: 2021 Document Type: Article Affiliation country: QMJ.2021.23

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Prognostic study / Screening study Language: English Journal: Qatar Med J Year: 2021 Document Type: Article Affiliation country: QMJ.2021.23