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Impact of COVID-19 Pandemic on Surgical Breast Cancer Patients Undergoing Neoadjuvant Therapy: A Multicentric Study.
Vanni, Gianluca; Pellicciaro, Marco; Combi, Francesca; Papi, Simona; Materazzo, Marco; Segattini, Silvia; Rizza, Stefano; Chiocchi, Marcello; Perretta, Tommaso; Meucci, Rosaria; Portarena, Ilaria; Pistolese, Chiara Adriana; Ielpo, Benedetto; Campanelli, Michela; Lisi, Giorgio; Chiaravalloti, Agostino; Tazzioli, Giovanni; Buonomo, Oreste Claudio.
  • Vanni G; Breast Unit, Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy.
  • Pellicciaro M; Breast Unit, Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy; marcopell62@gmail.com.
  • Combi F; Division of Breast Surgical Oncology Department of Medical and Surgery, Maternal-infantile and Adult Sciences, University Hospital of Modena and Reggio Emilila, Modena, Italy.
  • Papi S; Division of Breast Surgical Oncology Department of Medical and Surgery, Maternal-infantile and Adult Sciences, University Hospital of Modena and Reggio Emilila, Modena, Italy.
  • Materazzo M; Breast Unit, Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy.
  • Segattini S; Division of Breast Surgical Oncology Department of Medical and Surgery, Maternal-infantile and Adult Sciences, University Hospital of Modena and Reggio Emilila, Modena, Italy.
  • Rizza S; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
  • Chiocchi M; Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy, University of Rome, Rome, Italy.
  • Perretta T; Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy, University of Rome, Rome, Italy.
  • Meucci R; Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy, University of Rome, Rome, Italy.
  • Portarena I; Department of Oncology, Policlinico Tor Vergata University, Rome, Italy.
  • Pistolese CA; Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy, University of Rome, Rome, Italy.
  • Ielpo B; Unidad de Chirugia Hepatobiliopancreática, Hospital Universitario del Mar, Barcelona, Spain.
  • Campanelli M; Emergency Surgery Unit, University Hospital of Tor Vergata, Rome, Italy.
  • Lisi G; Department of Surgery, Sant'Eugenio Hospital, Rome, Italy.
  • Chiaravalloti A; Department of Biomedicine and Prevention, Policlinico Tor Vergata University, Rome, Italy.
  • Tazzioli G; IRCCS Neuromed, UOC Medicina Nucleare, Pozzilli, Italy.
  • Buonomo OC; Division of Breast Surgical Oncology Department of Medical and Surgery, Maternal-infantile and Adult Sciences, University Hospital of Modena and Reggio Emilila, Modena, Italy.
Anticancer Res ; 41(9): 4535-4542, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1395532
ABSTRACT
BACKGROUND/

AIM:

Due to the SARS-CoV-2 pandemic, many scientific committees proposed neoadjuvant therapy (NACT) bridging treatment as a novel strategy and indication. The aim of the study was to evaluate the impact of COVID-19 pandemic on breast cancer patients undergoing NACT. PATIENTS AND

METHODS:

All breast cancer patients referred to two Breast Units during COVID-19-pandemic were enrolled.

RESULTS:

Out of 814 patients, 43(5.3%) were enrolled in the COVID-19-group and compared with 94 (7.9%) similar Pre-COVID-19 patients. We observed a reduction in the number of patients undergoing NACT, p=0.0019. No difference was reported in terms of clinical presentation, indications, and tumor response. In contrast, a higher number of vascular adverse events was reported (6.9% vs. 0% p=0.029). Immediate breast cancer reconstructions following invasive surgery suffered a significant slowdown (5.9% vs. 47.7%, p=0.019).

CONCLUSION:

COVID-19 caused a reduction in the number of patients undergoing NACT, with no changes in terms of indications, clinical presentation, and tumor response. Furthermore, there was an increased incidence of vascular events.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Breast Neoplasms / Mammaplasty / Neoadjuvant Therapy / COVID-19 / Antineoplastic Agents Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Middle aged Language: English Journal: Anticancer Res Year: 2021 Document Type: Article Affiliation country: Anticanres.15265

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Breast Neoplasms / Mammaplasty / Neoadjuvant Therapy / COVID-19 / Antineoplastic Agents Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Middle aged Language: English Journal: Anticancer Res Year: 2021 Document Type: Article Affiliation country: Anticanres.15265