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Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol.
Sigfrid, Louise; Drake, Thomas M; Pauley, Ellen; Jesudason, Edwin C; Olliaro, Piero; Lim, Wei Shen; Gillesen, Annelies; Berry, Colin; Lowe, David J; McPeake, Joanne; Lone, Nazir; Munblit, Daniel; Cevik, Muge; Casey, Anna; Bannister, Peter; Russell, Clark D; Goodwin, Lynsey; Ho, Antonia; Turtle, Lance; O'Hara, Margaret E; Hastie, Claire; Donohue, Chloe; Spencer, Rebecca G; Donegan, Cara; Gummery, Alison; Harrison, Janet; Hardwick, Hayley E; Hastie, Claire E; Carson, Gail; Merson, Laura; Baillie, J Kenneth; Openshaw, Peter; Harrison, Ewen M; Docherty, Annemarie B; Semple, Malcolm G; Scott, Janet T.
  • Sigfrid L; Clinical Research Fellow, Public Health Specialist, ISARIC Global Support Centre, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.
  • Drake TM; Clinical Research Fellow, Centre for Medical Informatics, University of Edinburgh, Edinburgh, UK.
  • Pauley E; Medical Student, University of Edinburgh Medical School, Edinburgh, UK.
  • Jesudason EC; Consultant in Rehabilitation Medicine, NHS Lothian, Edinburgh, UK.
  • Olliaro P; Professor of Poverty Related Infectious Diseases, ISARIC Global Support Centre, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.
  • Lim WS; Honorary Professor of Respiratory Medicine, Department of Respiratory Medicine, Nottingham University Hospitals NHS Trust and University of Nottingham, UK.
  • Gillesen A; Senior Clinical Trial Nurse, ISARIC Global Support Centre, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.
  • Berry C; Professor of Cardiology and Imaging, Institute of Cardiovascular and Medical Sciences, University of Glasgow.
  • Lowe DJ; Consultant in Emergency Medicine, NHS Greater Glasgow and Clyde, Emergency Department, Glasgow, UK.
  • McPeake J; Nurse Consultant in Clinical Research, School of Medicine, Dentistry and Nursing, University of Glasgow, UK.
  • Lone N; Senior Clinical Lecturer in Critical Care, Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Munblit D; Professor of Paediatrics, Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child's Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
  • Cevik M; Clinical Senior Lecturer, Inflammation, Repair and Development Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK.
  • Casey A; Clinical Lecturer, Division of Infection and Global Health Research, University of St Andrews.
  • Bannister P; Medical Student, Brighton and Sussex Medical School, Brighton, UK.
  • Russell CD; Medical Student, Brighton and Sussex Medical School, Brighton, UK.
  • Goodwin L; Clinical Lecturer in Infectious Diseases, Centre for Inflammation Research, University of Edinburgh, UK.
  • Ho A; Specialist Registrar in Infectious Diseases and General Internal Medicine, Tropical and Infectious Diseases Unit, North Manchester General Hospital, Delaunays Rd, Manchester, UK.
  • Turtle L; Clinical Research Fellow, National Institute of Health Research (NIHR) Health Protection Research Unit in emerging and zoonotic infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
  • O'Hara ME; Clinical Senior Lecturer/Consultant in Infectious Diseases, MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
  • Hastie C; Senior Clinical Lecturer, NIHR Health Protection Research Unit in emerging and zoonotic infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
  • Donohue C; Consultant in Infectious Disease, Tropical and Infectious Disease Unit, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
  • Spencer RG; Patient-advocate, Long COVID Support, Birmingham, UK.
  • Donegan C; Patient-advocate, Long COVID Support, Birmingham, UK.
  • Gummery A; Trials Coordinator, Liverpool Clinical Trials Centre, University of Liverpool, Liverpool, UK.
  • Harrison J; Project Administrator, Institute of Infection, Veterinary and Ecological Sciences (IVES), University of Liverpool, Liverpool, UK.
  • Hardwick HE; Project Administrator, Institute of Infection, Veterinary and Ecological Sciences (IVES), University of Liverpool, Liverpool, UK.
  • Hastie CE; Project Administrator, Institute of Infection, Veterinary and Ecological Sciences (IVES), University of Liverpool, Liverpool, UK.
  • Carson G; Data Base Developer, National Institute of Health Research (NIHR) Health Protection research Unit in Emerging and Zoonotic Infections, Liverpool, UK.
  • Merson L; Institute of Infection and Global Health, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.
  • Baillie JK; Institute of Infection and Global Health, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.
  • Openshaw P; Project Manager, National Institute of Health Research (NIHR) Health Protection research Unit in Emerging and Zoonotic Infections, Liverpool, UK.
  • Harrison EM; Lecturer in Public Health, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
  • Docherty AB; Head, ISARIC Global Support Centre, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.
  • Semple MG; Head of Data, ISARIC Global Support Centre, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.
  • Scott JT; Senior Clinical Research Fellow, Roslin Institute, University of Edinburgh, Edinburgh, UK.
Lancet Reg Health Eur ; 8: 100186, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1397545
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT

BACKGROUND:

This study sought to establish the long-term effects of Covid-19 following hospitalisation.

METHODS:

327 hospitalised participants, with SARS-CoV-2 infection were recruited into a prospective multicentre cohort study at least 3 months post-discharge. The primary outcome was self-reported recovery at least ninety days after initial Covid-19 symptom onset. Secondary outcomes included new symptoms, disability (Washington group short scale), breathlessness (MRC Dyspnoea scale) and quality of life (EQ5D-5L).

FINDINGS:

55% of participants reported not feeling fully recovered. 93% reported persistent symptoms, with fatigue the most common (83%), followed by breathlessness (54%). 47% reported an increase in MRC dyspnoea scale of at least one grade. New or worse disability was reported by 24% of participants. The EQ5D-5L summary index was significantly worse following acute illness (median difference 0.1 points on a scale of 0 to 1, IQR -0.2 to 0.0). Females under the age of 50 years were five times less likely to report feeling recovered (adjusted OR 5.09, 95% CI 1.64 to 15.74), were more likely to have greater disability (adjusted OR 4.22, 95% CI 1.12 to 15.94), twice as likely to report worse fatigue (adjusted OR 2.06, 95% CI 0.81 to 3.31) and seven times more likely to become more breathless (adjusted OR 7.15, 95% CI 2.24 to 22.83) than men of the same age.

INTERPRETATION:

Survivors of Covid-19 experienced long-term symptoms, new disability, increased breathlessness, and reduced quality of life. These findings were present in young, previously healthy working age adults, and were most common in younger females.

FUNDING:

National Institute for Health Research, UK Medical Research Council, Wellcome Trust, Department for International Development and the Bill and Melinda Gates Foundation.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Clinical Practice Guide / Observational study Topics: Long Covid Language: English Journal: Lancet Reg Health Eur Year: 2021 Document Type: Article Affiliation country: J.lanepe.2021.100186

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Clinical Practice Guide / Observational study Topics: Long Covid Language: English Journal: Lancet Reg Health Eur Year: 2021 Document Type: Article Affiliation country: J.lanepe.2021.100186