Visible-Light-Induced Multicomponent Synthesis of γ-Amino Esters with Diazo Compounds.
Org Lett
; 23(16): 6278-6282, 2021 Aug 20.
Article
in English
| MEDLINE | ID: covidwho-1397832
ABSTRACT
A visible-light-induced multicomponent reaction of ethyl diazoacetate, diarylamines, and styrene-type alkenes is described. This novel 1,2-difunctionalization of alkenes can be readily achieved under a simple operation and mild conditions, affording γ-amino esters as major products. The reaction proceeds through the generation of carbon-centered radicals from diazo compounds by a visible-light-promoted proton-coupled electron transfer (PCET) process. The carbon radicals then add to diverse alkenes, delivering new carbon radical species, and the final products are formed with N-centered radicals via a radical-radical coupling.
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Database:
MEDLINE
Language:
English
Journal:
Org Lett
Journal subject:
Biochemistry
Year:
2021
Document Type:
Article
Affiliation country:
Acs.orglett.1c02071
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