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Visible-Light-Induced Multicomponent Synthesis of γ-Amino Esters with Diazo Compounds.
Ma, Na; Guo, Lin; Qi, Dan; Gao, Fei; Yang, Chao; Xia, Wujiong.
  • Ma N; State Key Lab of Urban Water Resource and Environment, School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.
  • Guo L; State Key Lab of Urban Water Resource and Environment, School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.
  • Qi D; State Key Lab of Urban Water Resource and Environment, School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.
  • Gao F; State Key Lab of Urban Water Resource and Environment, School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.
  • Yang C; State Key Lab of Urban Water Resource and Environment, School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.
  • Xia W; State Key Lab of Urban Water Resource and Environment, School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.
Org Lett ; 23(16): 6278-6282, 2021 Aug 20.
Article in English | MEDLINE | ID: covidwho-1397832
ABSTRACT
A visible-light-induced multicomponent reaction of ethyl diazoacetate, diarylamines, and styrene-type alkenes is described. This novel 1,2-difunctionalization of alkenes can be readily achieved under a simple operation and mild conditions, affording γ-amino esters as major products. The reaction proceeds through the generation of carbon-centered radicals from diazo compounds by a visible-light-promoted proton-coupled electron transfer (PCET) process. The carbon radicals then add to diverse alkenes, delivering new carbon radical species, and the final products are formed with N-centered radicals via a radical-radical coupling.

Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Org Lett Journal subject: Biochemistry Year: 2021 Document Type: Article Affiliation country: Acs.orglett.1c02071

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Org Lett Journal subject: Biochemistry Year: 2021 Document Type: Article Affiliation country: Acs.orglett.1c02071