Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19.
Nat Biotechnol
; 40(1): 110-120, 2022 01.
Article
in English
| MEDLINE | ID: covidwho-1397879
ABSTRACT
A better understanding of the metabolic alterations in immune cells during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may elucidate the wide diversity of clinical symptoms experienced by individuals with coronavirus disease 2019 (COVID-19). Here, we report the metabolic changes associated with the peripheral immune response of 198 individuals with COVID-19 through an integrated analysis of plasma metabolite and protein levels as well as single-cell multiomics analyses from serial blood draws collected during the first week after clinical diagnosis. We document the emergence of rare but metabolically dominant T cell subpopulations and find that increasing disease severity correlates with a bifurcation of monocytes into two metabolically distinct subsets. This integrated analysis reveals a robust interplay between plasma metabolites and cell-type-specific metabolic reprogramming networks that is associated with disease severity and could predict survival.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Monocytes
/
T-Lymphocytes
/
Single-Cell Analysis
/
COVID-19
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Nat Biotechnol
Journal subject:
Biotechnology
Year:
2022
Document Type:
Article
Affiliation country:
S41587-021-01020-4
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