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Association of coagulation disturbances with severity of COVID-19: a longitudinal study.
Lu, Huimin; Chen, Ming; Tang, Shaoqiu; Yu, Wenkui.
  • Lu H; Department of Intensive Care Unit, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing, People's Republic of China.
  • Chen M; Department of Intensive Care Unit, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing, People's Republic of China.
  • Tang S; Department of General Practice, Nanjing University Hospital, Nanjing, People's Republic of China.
  • Yu W; Department of Intensive Care Unit, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing, People's Republic of China.
Hematology ; 26(1): 656-662, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1398020
ABSTRACT

OBJECTIVES:

Coagulation dysfunction is an evident factor in the clinical diagnosis and treatment of patients with coronavirus disease 2019 (COVID-19), appearing even in COVID-19 patients with normal inflammation indices. Therefore, this study aimed to analyze the characteristics of coagulation function indices in COVID-19 patients to investigate possible mechanisms through the comparison of non-severe and severe COVID-19 patients.

METHODS:

We included 143 patients whose clinical characteristics, coagulation function, and other indices such as inflammatory factors were collected and compared based on disease severity.

RESULTS:

Activated partial thromboplastin time (APTT), D-dimer, and fibrinogen levels were evidently higher in the severe group than in the non-severe group. Among non-severe COVID-19 patients, the aforementioned indicators depicted increasing trends, but the fibrinogen level alone was higher than normal. However, in severe COVID-19 patients, values of all three indices were higher than normal. In severe COVID-19 patients, fibrinogen and D-dimer were correlated with several inflammation indices during the early stage of the disease. However, no correlation between fibrinogen and inflammatory factors was observed in non-severe COVID-19 patients at any time point.

DISCUSSION:

Results revealed that the hypercoagulability tendency of severe COVID-19 patients was more evident. The relationship between coagulation function and inflammatory factors showed that changes in coagulation function in severe COVID-19 patients may be related to abnormal increase in inflammatory factors at an early stage; however, in non-severe COVID-19 patients, there might be other factors leading to abnormal coagulation.

CONCLUSION:

Inflammatory factors were not the only cause of abnormal coagulation function in COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Coagulation / Thrombophilia / Disseminated Intravascular Coagulation / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Hematology Journal subject: Hematology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Coagulation / Thrombophilia / Disseminated Intravascular Coagulation / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Hematology Journal subject: Hematology Year: 2021 Document Type: Article