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SARS-CoV-2 infection and disease outcomes in non-human primate models: advances and implications.
Yuan, Lunzhi; Tang, Qiyi; Zhu, Huachen; Guan, Yi; Cheng, Tong; Xia, Ningshao.
  • Yuan L; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, People's Republic of China.
  • Tang Q; Department of Microbiology, Howard University College of Medicine, Washington, DC, USA.
  • Zhu H; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, People's Republic of China.
  • Guan Y; Joint Institute of Virology (Shantou University and The University of Hong Kong), Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases, Shantou University, Shantou, People's Republic of China.
  • Cheng T; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, People's Republic of China.
  • Xia N; Joint Institute of Virology (Shantou University and The University of Hong Kong), Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases, Shantou University, Shantou, People's Republic of China.
Emerg Microbes Infect ; 10(1): 1881-1889, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1398037
ABSTRACT
SARS-CoV-2 has been the causative pathogen of the pandemic of COVID-19, resulting in catastrophic health issues globally. It is important to develop human-like animal models for investigating the mechanisms that SARS-CoV-2 uses to infect humans and cause COVID-19. Several studies demonstrated that the non-human primate (NHP) is permissive for SARS-CoV-2 infection to cause typical clinical symptoms including fever, cough, breathing difficulty, and other diagnostic abnormalities such as immunopathogenesis and hyperplastic lesions in the lung. These NHP models have been used for investigating the potential infection route and host immune response to SARS-CoV-2, as well as testing vaccines and drugs. This review aims to summarize the benefits and caveats of NHP models currently available for SARS-CoV-2, and to discuss key topics including model optimization, extended application, and clinical translation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Primates / Disease Models, Animal / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Prognostic study Topics: Vaccines Limits: Animals / Humans Language: English Journal: Emerg Microbes Infect Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Primates / Disease Models, Animal / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Prognostic study Topics: Vaccines Limits: Animals / Humans Language: English Journal: Emerg Microbes Infect Year: 2021 Document Type: Article