Treatment Options for COVID-19-Related Guillain-Barré Syndrome: A Systematic Review of Literature.
Neurologist
; 26(5): 196-224, 2021 Sep 07.
Article
in English
| MEDLINE | ID: covidwho-1398198
ABSTRACT
BACKGROUND:
Central nervous system complications are reported in an increasing number of patients with Coronavirus Disease 2019 (COVID-19). COVID-19-related Guillain-Barré syndrome (GBS) is of particular importance given its association with higher mortality rates and prolonged respiratory failure. REVIEWSUMMARY:
We conducted a systematic review of published cases for COVID-19-related GBS, and provide a summary of clinical management strategies for these cases. Sixty-three studies, including 86 patients, were included. Seventy-six cases with reported outcome data were eligible for the outcome analysis. Ninety-nine percent of patients were diagnosed with COVID-19 before diagnosis of GBS (median 14 d prior, interquartile range 7 to 20). Intravenous immunotherapy (intravenous immunoglobulin 0.4 g/kg/d for 5 d) was the most frequently used treatment approach. The review indicated that the outcome was not favorable in 26% of cases (persistent neurological deficits). A mortality rate of 3.5% was observed in patients with COVID-19-related GBS.CONCLUSIONS:
Although evidence to support specific treatments is lacking, clinicians should consider the benefits of immunotherapy and plasma exchange in addition to the standard antimicrobial and supportive therapies for patients who meet the diagnostic criteria for acute sensory and motor polyradiculoneuritis. Intravenous immunoglobulin treatment alone is not shown to result in improved outcomes or mortality. More extensive studies aimed at exploring the neurological manifestations and complications of COVID-19 and distinctive treatment options for COVID-19-related GBS are warranted.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Thyroid Neoplasms
/
Immunoglobulins, Intravenous
/
Guillain-Barre Syndrome
/
SARS-CoV-2
/
COVID-19 Drug Treatment
Type of study:
Diagnostic study
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Neurologist
Journal subject:
Neurology
Year:
2021
Document Type:
Article
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