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Early experience of COVID-19 vaccination in adults with systemic rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey.
Sattui, Sebastian Eduardo; Liew, Jean W; Kennedy, Kevin; Sirotich, Emily; Putman, Michael; Moni, Tarin T; Akpabio, Akpabio; Alpízar-Rodríguez, Deshiré; Berenbaum, Francis; Bulina, Inita; Conway, Richard; Singh, Aman Dev; Duff, Eimear; Durrant, Karen L; Gheita, Tamer A; Hill, Catherine L; Howard, Richard A; Hoyer, Bimba F; Hsieh, Evelyn; El Kibbi, Lina; Kilian, Adam; Kim, Alfred Hyoungju; Liew, David F L; Lo, Chieh; Miller, Bruce; Mingolla, Serena; Nudel, Michal; Palmerlee, Candace A; Singh, Jasvinder A; Singh, Namrata; Ugarte-Gil, Manuel Francisco; Wallace, John; Young, Kristen J; Bhana, Suleman; Costello, Wendy; Grainger, Rebecca; Machado, Pedro M; Robinson, Philip C; Sufka, Paul; Wallace, Zachary S; Yazdany, Jinoos; Harrison, Carly; Larché, Maggie; Levine, Mitchell; Foster, Gary; Thabane, Lehana; Rider, Lisa G; Hausmann, Jonathan S; Simard, Julia F; Sparks, Jeffrey A.
  • Sattui SE; Division of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
  • Liew JW; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts, USA.
  • Kennedy K; Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
  • Sirotich E; Medicine, McMaster University, Hamilton, Ontario, Canada.
  • Putman M; Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Moni TT; Department of Biochemistry & Biomedical Sciences, McMaster University Faculty of Science, Hamilton, Ontario, Canada.
  • Akpabio A; Rheumatology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
  • Alpízar-Rodríguez D; Research Unit, Mexican College of Rheumatology, Coyoacan, Ciudad de México, Mexico.
  • Berenbaum F; Rheumatology, Sorbonne Université, Paris, France.
  • Bulina I; Department of Internal Diseases, Rheumatology Centre, Paul Stradins Clinical University Hospital, Riga, Latvia.
  • Conway R; Rheumatology, Saint James's Hospital, Dublin, Ireland.
  • Singh AD; Community Medicine, GMC Patiala, Punjab, India.
  • Duff E; Department of Rheumatology, Saint James's Hospital, Dublin, Ireland.
  • Durrant KL; Autoinflammatory Alliance, San Francisco, California, USA.
  • Gheita TA; Rheumatology and Clinical Immunology, Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Hill CL; Rheumatology Department, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia.
  • Howard RA; Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
  • Hoyer BF; Spondylitis Association of America, Van Nuys, California, USA.
  • Hsieh E; Medical Department I, Department for Rheumatology and Clinical Immunology, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Schleswig-Holstein, Germany.
  • El Kibbi L; Section of Rheumatology, Allergy & Immunology, Yale School of Medicine, New Haven, Connecticut, USA.
  • Kilian A; Section of Rheumatology, VA Connecticut Healthcare System-West Haven Campus, West Haven, Connecticut, USA.
  • Kim AH; Rheumatology, Specialized Medical Center Hospital, Riyadh, Saudi Arabia.
  • Liew DFL; Department of Internal Medicine, Division of Rheumatology, Saint Louis University, Saint Louis, Missouri, USA.
  • Lo C; Medicine/Rheumatology, Washington University in Saint Louis School of Medicine, Saint Louis, Missouri, USA.
  • Miller B; Rheumatology, Austin Health, Heidelberg West, Victoria, Australia.
  • Mingolla S; Clinical Pharmacology and Therapeutics, Austin Health, Heidelberg, Victoria, Australia.
  • Nudel M; I-Shou University College of Medicine, Yanchau Sheng, Taiwan.
  • Palmerlee CA; Medicine, University of California San Diego, La Jolla, California, USA.
  • Singh JA; Italian National Patient Association for Rehumatoid and Rare Disease (APMARR), Rome, Italy.
  • Singh N; The Israeli Association for RMD Patients "Mifrakim Tz'eirim", Haifa, Israel.
  • Ugarte-Gil MF; Relapsing Polychondritis Foundation, International Relapsing Polychondritis Research Network, Walnut Creek, California, USA.
  • Wallace J; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Young KJ; Medicine Service, Birmingham Veterans Affairs Medical Center, Birmingham, Alabama, USA.
  • Bhana S; Medicine, Division of Rheumatology, University of Washington, Seattle, Washington, USA.
  • Costello W; Department of Rheumatology, Universidad Cientifica del Sur, Lima, Peru.
  • Grainger R; Universidad Científica del Sur, Lima, Peru.
  • Machado PM; Autoinflammatory UK, Edinburgh, UK.
  • Robinson PC; Division of Rheumatology, University of Texas Southwestern Medical School, Dallas, Texas, USA.
  • Sufka P; Crystal Run Healthcare, Middletown, New York, USA.
  • Wallace ZS; Irish Children's Arthritis Network (iCAN), Tipperary, Ireland.
  • Yazdany J; Department of Medicine, Malaghan Institute of Medical Research, Wellington, New Zealand.
  • Harrison C; MRC Centre for Neuromuscular Diseases, University College London, London, UK.
  • Larché M; Rheumatology, University College London Centre for Rheumatology, London, UK.
  • Levine M; Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia.
  • Foster G; Metro North Hospital & Health Service, Royal Brisbane and Woman's Hospital Health Service District, Herston, Queensland, Australia.
  • Thabane L; Healthpartners, St Paul, Minnesota, USA.
  • Rider LG; Clinical Epidemiology Program and Rheumatology Unit, Division of Rheumatology,Allergy, and Immunology, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Hausmann JS; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • Simard JF; Medicine/Rheumatology, University of California, San Francisco, California, USA.
  • Sparks JA; LupusChat, New York, New York, USA.
RMD Open ; 7(3)2021 09.
Article in English | MEDLINE | ID: covidwho-1398725
ABSTRACT

BACKGROUND:

We describe the early experiences of adults with systemic rheumatic disease who received the COVID-19 vaccine.

METHODS:

From 2 April to 30 April 2021, we conducted an online, international survey of adults with systemic rheumatic disease who received COVID-19 vaccination. We collected patient-reported data on clinician communication, beliefs and intent about discontinuing disease-modifying antirheumatic drugs (DMARDs) around the time of vaccination, and patient-reported adverse events after vaccination.

RESULTS:

We analysed 2860 adults with systemic rheumatic diseases who received COVID-19 vaccination (mean age 55.3 years, 86.7% female, 86.3% white). Types of COVID-19 vaccines were Pfizer-BioNTech (53.2%), Oxford/AstraZeneca (22.6%), Moderna (21.3%), Janssen/Johnson & Johnson (1.7%) and others (1.2%). The most common rheumatic disease was rheumatoid arthritis (42.3%), and 81.2% of respondents were on a DMARD. The majority (81.9%) reported communicating with clinicians about vaccination. Most (66.9%) were willing to temporarily discontinue DMARDs to improve vaccine efficacy, although many (44.3%) were concerned about rheumatic disease flares. After vaccination, the most reported patient-reported adverse events were fatigue/somnolence (33.4%), headache (27.7%), muscle/joint pains (22.8%) and fever/chills (19.9%). Rheumatic disease flares that required medication changes occurred in 4.6%.

CONCLUSION:

Among adults with systemic rheumatic disease who received COVID-19 vaccination, patient-reported adverse events were typical of those reported in the general population. Most patients were willing to temporarily discontinue DMARDs to improve vaccine efficacy. The relatively low frequency of rheumatic disease flare requiring medications was reassuring.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Rheumatology / Rheumatic Diseases / COVID-19 Type of study: Observational study / Qualitative research / Randomized controlled trials Topics: Vaccines Limits: Adult / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Rmdopen-2021-001814

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Rheumatology / Rheumatic Diseases / COVID-19 Type of study: Observational study / Qualitative research / Randomized controlled trials Topics: Vaccines Limits: Adult / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Rmdopen-2021-001814