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The Effect of Plant Metabolites on Coronaviruses: A Comprehensive Review Focusing on their IC50 Values and Molecular Docking Scores.
Farshi, Parastou; Kaya, Eda Ceren; Hashempour-Baltork, Fataneh; Khosravi-Drani, Kianoush.
  • Farshi P; Food Science Institute, Kansas State University, Manhattan, Kansas 66506-0500, USA.
  • Kaya EC; Food Science Institute, Kansas State University, Manhattan, Kansas 66506-0500, USA.
  • Hashempour-Baltork F; Department of Food Science and Technology, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Science and Food Technology, Shahid Beheshti, University of Medical Sciences, Tehran, Iran.
  • Khosravi-Drani K; Department of Food Science and Technology, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Science and Food Technology, Shahid Beheshti, University of Medical Sciences, Tehran, Iran.
Mini Rev Med Chem ; 22(3): 457-483, 2022.
Article in English | MEDLINE | ID: covidwho-1399062
ABSTRACT
Coronaviruses have caused worldwide outbreaks in different periods. SARS (severe acute respiratory syndrome) was the first emerged virus from this family, followed by MERS (Middle East respiratory syndrome) and SARS-CoV-2 (2019-nCoV or COVID 19), which is newly emerged. Many studies have been conducted on the application of chemical and natural drugs for treating these coronaviruses and they are mostly focused on inhibiting the proteases of viruses or blocking their protein receptors through binding to amino acid residues. Among many substances which are introduced to have an inhibitory effect against coronaviruses through the mentioned pathways, natural components are of specific interest. Secondary and primary metabolites from plants, are considered as potential drugs to have an inhibitory effect on coronaviruses. IC50 value (the concentration in which there is 50% loss in enzyme activity), molecular docking score and binding energy are parameters to understand the ability of metabolites to inhibit the specific virus. In this study we reviewed 154 papers on the effect of plant metabolites on different coronaviruses and data of their IC50 values, molecular docking scores and inhibition percentages are collected in tables. Secondary plant metabolites such as polyphenol, alkaloids, terpenoids, organosulfur compounds, saponins and saikosaponins, lectins, essential oil, and nicotianamine, and primary metabolites such as vitamins are included in this study.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Phytochemicals / SARS-CoV-2 Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Mini Rev Med Chem Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: 1389557521666210831152511

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Phytochemicals / SARS-CoV-2 Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Mini Rev Med Chem Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: 1389557521666210831152511