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Decrease of left ventricular ejection fraction in severe illness patients due to COVID-19 may improve as the disease resolves
Demirkiran, Aykut; Onar, Lütfi Çagatay; Dogan, Mustafa.
  • Demirkiran A; Department of Cardiology, Tekirdag Dr. Ismail Fehmi Cumalioglu City Hospital, Tekirdag, Turkey.
  • Onar LÇ; Department of Cardiovascular Surgery, Tekirdag Dr. Ismail Fehmi Cumalioglu City Hospital, Tekirdag, Turkey.
  • Dogan M; Department of Infectious Diseases and Clinical Microbiology, Tekirdag Namik Kemal University, Tekirdag, Turkey.
Turk J Med Sci ; 51(6): 2861-2869, 2021 12 13.
Article in English | MEDLINE | ID: covidwho-1399424
ABSTRACT
Background/

aim:

Increase in publications supporting myocardial involvement in the COVID-19 disease has led to need to gain insight into the the global burden of heart failure after pandemic. We examined the course of myocardial systolic function in patients without elevated troponin levels. Materials and

methods:

We performed a prospective study. Patients with high troponin levels were excluded from the study in order to definitively exclude complications known to cause permanent left ventricular systolic dysfunction, such as acute coronary syndromes. Two echocardiographic examinations were performed. The first evaluation was performed within the days of hospitalization, if possible, on the day when dyspnea is severe. The second evaluation was performed during the outpatient clinic controls one month after the patient was recovered. Left ventricular ejection fraction (LVEF) was measured using the biplane method of disks (modified Simpson's rule).

Results:

In the first evaluation, LVEF was found to be significantly lower in the severe illness group than mild/moderate illness group (50 ± 6% and 59 ± 6%; p = 0.03). LVEF decrease (<50%) was found in fifteen patients (43 ± 4%) and detected as global hypokinesia but not segmental. All of these patients were in the severe illness group. In the second evaluation, LVEFs of the fifteen patients with decreased LVEF in the first evaluation were improved and detected in normal limits (first evaluation = 43 ± 4% and second evaluation = 55 ± 2%, p = 0.01).

Conclusion:

Considering patients without elevated troponin levels during COVID-19 infection, no permanent systolic dysfunction was detected after first month of recovery. We found that transient myocardial dysfunction may develop in the severe illness group with normal troponin levels, LVEF may decrease in the acute phase and improve with the recovery period.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Troponin / Ventricular Function, Left / Ventricular Dysfunction, Left / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Turk J Med Sci Year: 2021 Document Type: Article Affiliation country: Sag-2101-198

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Troponin / Ventricular Function, Left / Ventricular Dysfunction, Left / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Turk J Med Sci Year: 2021 Document Type: Article Affiliation country: Sag-2101-198