Epidemiological characteristics and outcomes from 187 patients with COVID-19 admitted to 6 reference centers in Greece: an observational study during the first wave of the COVID-19 pandemic.
Adv Respir Med
; 89(4): 378-385, 2021.
Article
in English
| MEDLINE | ID: covidwho-1399543
ABSTRACT
INTRODUCTION:
Epidemiological data from patients with COVID-19 has been recently published in several countries. Nationwide data of hospitalized patients with COVID-19 in Greece remain scarce. MATERIAL ANDMETHODS:
This was an observational, retrospective study from 6 reference centers between February 26 and May 15, 2020.RESULTS:
The patients were mostly males (65.7%) and never smokers (57.2%) of median age 60 (95% CI 57.6-64) years. The majority of the subjects (98%) were treated with the standard-of-care therapeutic regimen at that time, including hydroxychlo-roquine and azithromycin. Median time of hospitalization was 10 days (95% CI 10-12). Twenty-five (13.3%) individuals were intubated and 8 died (4.2%). The patients with high neutrophil-to-lymphocyte ratio (NLR) ( > 3.58) exhibited more severe disease as indicated by significantly increased World Health Organization (WHO) R&D ordinal scale (4; 95% CI 4-4 vs 3; 95% CI 3-4, p = 0.0001) and MaxFiO2% (50; 95% CI 38.2-50 vs 29.5; 95% CI 21-31, p < 0.0001). The patients with increased lactate dehydrogenase (LDH) levels ( > 270 IU/ml) also exhibited more advanced disease compared to the low LDH group ( < 270 IU/ml) as indicated by both WHO R&D ordinal scale (4; 95% CI 4-4 vs 4; 95% CI 3-4, p = 0.0001) and MaxFiO2% (50; 95% CI 35-60 vs 28; 95% CI 21-31, p < 0.0001).CONCLUSION:
We present the first epidemiological report from a low-incidence and mortality COVID-19 country. NLR and LDH may represent reliable disease prognosticators leading to timely treatment decisions.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Severity of Illness Index
/
Critical Care
/
COVID-19
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
English
Journal:
Adv Respir Med
Year:
2021
Document Type:
Article
Affiliation country:
ARM.a2021.0087
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