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Differences and similarities of multisystem inflammatory syndrome in children, Kawasaki disease and macrophage activating syndrome due to systemic juvenile idiopathic arthritis: a comparative study.
Otar Yener, Gülçin; Paç Kisaarslan, Aysenur; Ulu, Kadir; Atalay, Erdal; Haslak, Fatih; Özdel, Semanur; Bozkaya Yücel, Burcu; Gezgin Yildirim, Deniz; Çakmak, Figen; Öztürk, Kübra; Çakan, Mustafa; Balik, Zeynep; Hasbal Akkus, Canan; Yildiz, Mehmet; Erat, Tugba; Çetin, Benhur Sirvan; Yilmaz, Münevver; Baglan, Esra; Laçinel Gürlevik, Sibel; Atasayan, Vildan; Karadag, Serife Gül; Adrovic, Amra; Çaglayan, Sengül; Tanatar, Ayse; Demirkan, Fatma Gül; Coskuner, Taner; Akgün, Özlem; Kasap Cüceoglu, Müserref; Kavrul Kayaalp, Gülsah; Sahin, Sezgin; Basaran, Özge; Demir, Ferhat; Barut, Kenan; Çiftel, Murat; Gürses, Dolunay; Baykan, Ali; Özsürekçi, Yasemin; Karagöz, Tevfik; Sönmez, Hafize Emine; Bilginer, Yelda; Aktay Ayaz, Nuray; Aydog, Özlem; Yüksel, Selçuk; Sözeri, Betül; Kasapçopur, Özgür; Özen, Seza.
  • Otar Yener G; Department of Pediatric Rheumatology, Sanliurfa Research and Training Hospital, Yenice Mah Yenice Yolu No. 1, Sanliurfa, Turkey. gulcinotar@gmail.com.
  • Paç Kisaarslan A; Pediatric Rheumatology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
  • Ulu K; Pediatric Rheumatology, University of Health Sciences, Ümraniye Research and Training Hospital, Istanbul, Turkey.
  • Atalay E; Pediatric Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
  • Haslak F; Pediatric Rheumatology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Özdel S; Pediatric Rheumatology, University of Health Sciences, Dr. Sami Ulus Maternity and Child Health and Diseases Research and Training Hospital, Ankara, Turkey.
  • Bozkaya Yücel B; Pediatric Rheumatology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
  • Gezgin Yildirim D; Pediatric Rheumatology, Diyarbakir Training and Research Hospital, Diyarbakir, Turkey.
  • Çakmak F; Pediatric Rheumatology, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Öztürk K; Pediatric Rheumatology, Istanbul Medeniyet University, Göztepe Prof. Dr. Süleyman Yalçin City Hospital, Istanbul, Turkey.
  • Çakan M; Pediatric Rheumatology, University of Health Sciences, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, Istanbul, Turkey.
  • Balik Z; Pediatric Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
  • Hasbal Akkus C; Pediatrics, University of Health Sciences, Ümraniye Research and Training Hospital, Istanbul, Turkey.
  • Yildiz M; Pediatric Rheumatology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Erat T; Pediatric Infectious Diseases, Sanliurfa Research and Training Hospital, Sanliurfa, Turkey.
  • Çetin BS; Pediatric Infectious Diseases, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
  • Yilmaz M; Pediatric Cardiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
  • Baglan E; Pediatric Rheumatology, University of Health Sciences, Dr. Sami Ulus Maternity and Child Health and Diseases Research and Training Hospital, Ankara, Turkey.
  • Laçinel Gürlevik S; Pediatric Infectious Diseases, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
  • Atasayan V; Pediatric Cardiology, University of Health Sciences, Ümraniye Research and Training Hospital, Istanbul, Turkey.
  • Karadag SG; Pediatric Rheumatology, Erzurum Regional Research and Training Hospital, Erzurum, Turkey.
  • Adrovic A; Pediatric Rheumatology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Çaglayan S; Pediatric Rheumatology, University of Health Sciences, Ümraniye Research and Training Hospital, Istanbul, Turkey.
  • Tanatar A; Pediatric Rheumatology, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Demirkan FG; Pediatric Rheumatology, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Coskuner T; Pediatric Rheumatology, University of Health Sciences, Ümraniye Research and Training Hospital, Istanbul, Turkey.
  • Akgün Ö; Pediatric Rheumatology, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Kasap Cüceoglu M; Pediatric Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
  • Kavrul Kayaalp G; Pediatric Rheumatology, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Sahin S; Pediatric Rheumatology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Basaran Ö; Pediatric Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
  • Demir F; Pediatric Rheumatology, University of Health Sciences, Ümraniye Research and Training Hospital, Istanbul, Turkey.
  • Barut K; Pediatric Rheumatology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Çiftel M; Pediatric Cardiology, Sanliurfa Research and Training Hospital, Sanliurfa, Turkey.
  • Gürses D; Pediatric Cardiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
  • Baykan A; Pediatric Cardiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
  • Özsürekçi Y; Pediatric Infectious Diseases, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
  • Karagöz T; Pediatric Cardiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
  • Sönmez HE; Pediatric Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.
  • Bilginer Y; Pediatric Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
  • Aktay Ayaz N; Pediatric Rheumatology, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Aydog Ö; Pediatric Rheumatology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
  • Yüksel S; Pediatric Rheumatology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
  • Sözeri B; Pediatric Rheumatology, University of Health Sciences, Ümraniye Research and Training Hospital, Istanbul, Turkey.
  • Kasapçopur Ö; Pediatric Rheumatology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Özen S; Pediatric Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Rheumatol Int ; 42(5): 879-889, 2022 05.
Article in English | MEDLINE | ID: covidwho-1400097
ABSTRACT
To compare the clinical and laboratory findings of multisystem inflammatory syndrome in children (MIS-C), patients with Kawasaki disease (KD) and with macrophage activating syndrome due to systemic juvenile idiopathic arthritis (sJIA-MAS) on real-life data. Patients diagnosed with MIS-C, KD, and sJIA-MAS from 12 different centers in Turkey who were followed for at least 6 months were included in the study. Demographic, clinical, and laboratory findings of all patients were analyzed. A total of 154 MIS-C, 59 KD, and 31 sJIA-MAS patients were included. The median age of patients with MIS-C were higher than those with KD while lower than those with sJIA-MAS (8.2, 3, 12 years, respectively). Myalgia (39.6%), cardiac (50.6%), gastrointestinal (72.7%), and neurological (22.1%) involvements were more common in patients with MIS-C compared to others. MIS-C patients had lower levels of lymphocyte (950 vs 1700 cells/µl) and thrombocyte (173,000 vs 355,000 cells/µl) counts and higher pro-BNP (1108 vs 55 pg/ml) levels than KD. Ferritin levels were higher in patients with MIS-C compared to patients with KD while they were lower than patients with sJIA-MAS (440, 170, 10,442 ng/ml, respectively). Patients with MIS-C had a shorter duration of hospitalization than sJIA-MAS (p = 0.02) while they required intensive care unit admission more frequently (55 vs 8 patients, p < 0.001). The median MAS/sJIA score of MIS-C patients was - 1.64 (- 5.23 to 9.68) and the median MAS/sJIA score of sJIA-MAS patients was -2.81 ([- 3.79] to [- 1.27]). MIS-C patients displayed certain differences in clinical and laboratory features when compared to KD and sJIA-MAS. Definition of the differences and similarities between MIS-C and the other intense inflammatory syndromes of childhood such as KD and MAS will help the clinicians while making timely diagnosis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Arthritis, Juvenile / Macrophage Activation Syndrome / Mucocutaneous Lymph Node Syndrome Type of study: Diagnostic study / Prognostic study Topics: Long Covid Limits: Child / Humans Language: English Journal: Rheumatol Int Year: 2022 Document Type: Article Affiliation country: S00296-021-04980-7

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Arthritis, Juvenile / Macrophage Activation Syndrome / Mucocutaneous Lymph Node Syndrome Type of study: Diagnostic study / Prognostic study Topics: Long Covid Limits: Child / Humans Language: English Journal: Rheumatol Int Year: 2022 Document Type: Article Affiliation country: S00296-021-04980-7