Cryo-electron tomography of enveloped viruses.
Trends Biochem Sci
; 47(2): 173-186, 2022 02.
Article
in English
| MEDLINE | ID: covidwho-1400539
ABSTRACT
Viruses are macromolecular machineries that hijack cellular metabolism for replication. Enveloped viruses comprise a large variety of RNA and DNA viruses, many of which are notorious human or animal pathogens. Despite their importance, the presence of lipid bilayers in their assembly has made most enveloped viruses too pleomorphic to be reconstructed as a whole by traditional structural biology methods. Furthermore, structural biology of the viral lifecycle was hindered by the sample thickness. Here, I review the recent advances in the applications of cryo-electron tomography (cryo-ET) on enveloped viral structures and intracellular viral activities.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Viruses
/
Electron Microscope Tomography
Limits:
Animals
Language:
English
Journal:
Trends Biochem Sci
Year:
2022
Document Type:
Article
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